Articular Cartilage: Evaluation with Fluid-suppressed 7.0-T Sodium MR Imaging in Subjects with and Subjects without Osteoarthritis
Articular Cartilage: Evaluation with Fluid-suppressed 7.0-T Sodium MR Imaging in Subjects with and Subjects without Osteoarthritis
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DOI：
10.1148/radiol.13121511
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发表时间：
2013-08-01
期刊：
影响因子：
19.7
通讯作者：
Regatte, Ravinder R.
中科院分区：
文献类型：
--
作者：
Madelin, Guillaume;Babb, James;Regatte, Ravinder R.
目的：为了评估潜在的使用钠磁共振（MR）成像的软骨，有和没有液体抑制，通过使用绝热脉冲，对受试者进行分类与受试者没有骨关节炎在7.0 T。材料和方法：该研究是由机构审查委员会批准，并符合健康保险及责任法案。对19名无症状受试者（对照受试者）和28名有症状受试者（骨关节炎患者）的膝关节软骨进行7.0 T钠MR成像，使用两种不同的序列：一种无液体抑制（径向三维序列），一种有液体抑制（反转恢复[IR]宽带均匀速率和平滑截断[WURST]）。通过使用具有绝热反转脉冲（WURST脉冲）的IR获得流体抑制。在每个受试者的髌骨、股胫内侧和外侧软骨区域测量四个连续切片的平均钠浓度及其标准差。计算每例受试者所有测量值的最小值、最大值、中位数和平均值以及标准差。通过使用逻辑回归和受试者工作特征曲线下面积（AUC）评价这些指标在骨关节炎检测中的效用。Bonferroni校正应用于P值与logistic regression.Results获得：从IR WURST的测量被发现是所有骨关节炎（Kelling-Lawrence评分为1-4）和早期骨关节炎（Kelling-Lawrence评分为1或2）的显着预测。最小标准差提供了最高的AUC（0.83），具有最高的准确性（>78%），灵敏度（>82%）和特异性（>74%）为所有骨关节炎和早期骨关节炎groups.Conclusion：定量钠MR成像在7.0 T与液体抑制使用绝热IR是骨关节炎的一个潜在的生物标志物。(C)RSNA，2013年
Purpose: To assess the potential use of sodium magnetic resonance (MR) imaging of cartilage, with and without fluid suppression by using an adiabatic pulse, for classifying subjects with versus subjects without osteoarthritis at 7.0 T.Materials and Methods: The study was approved by the institutional review board and was compliant with HIPAA. The knee cartilage of 19 asymptomatic (control subjects) and 28 symptomatic (osteoarthritis patients) subjects underwent 7.0-T sodium MR imaging with use of two different sequences: one without fluid suppression (radial three-dimensional sequence) and one with fluid suppression (inversion recovery [IR]wideband uniform rate and smooth truncation [WURST]). Fluid suppression was obtained by using IR with an adiabatic inversion pulse (WURST pulse). Mean sodium concentrations and their standard deviations were measured in the patellar, femorotibial medial, and lateral cartilage regions over four consecutive sections for each subject. The minimum, maximum, median, and average means and standard deviations were calculated over all measurements for each subject. The utility of these measures in the detection of osteoarthritis was evaluated by using logistic regression and the area under the receiver operating characteristic curve (AUC). Bonferroni correction was applied to the P values obtained with logistic regression.Results: Measurements from IR WURST were found to be significant predicators of all osteoarthritis (Kellgren-Lawrence score of 1-4) and early osteoarthritis (Kellgren-Lawrence score of 1 or 2). The minimum standard deviation provided the highest AUC (0.83) with the highest accuracy (>78%), sensitivity (>82%), and specificity (>74%) for both all osteoarthritis and early osteoarthritis groups.Conclusion: Quantitative sodium MR imaging at 7.0 T with fluid suppression by using adiabatic IR is a potential biomarker for osteoarthritis. (C) RSNA, 2013