In vivo mapping of gray matter loss with voxel-based morphometry in mild Alzheimer's disease
In vivo mapping of gray matter loss with voxel-based morphometry in mild Alzheimer's disease
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DOI：
10.1006/nimg.2001.0848
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发表时间：
2001-08-01
期刊：
影响因子：
5.7
通讯作者：
Eustache, F
中科院分区：
文献类型：
--
作者：
Baron, JC;Chételat, G;Eustache, F
到目前为止，阿尔茨海默病（AD）中区域性灰质萎缩的研究已经用感兴趣区域进行了评估，但这种方法耗时，依赖于观察者，并且重现性差（特别是在皮质区域边界方面），此外不适合提供对大脑的全面评估。在这项研究中，我们通过基于体素的形态测量法在19名轻度AD患者和16名年龄和性别比例相似的健康受试者的T1加权MRI体积集上绘制了灰质密度图，并报告了几乎对称分布的高度显着的灰质损失集群，主要影响内侧颞叶结构，后扣带回和相邻的楔前叶，以及颞顶联合和侧裂周新皮层，只有额叶轻微萎缩。研究结果进行了讨论，根据以往的研究，无论是在死后或神经影像学数据的基础上，并在PET研究的静息葡萄糖消耗量在AD灰质萎缩。该方法的局限性也进行了详细讨论，特别是相对于分割和空间归一化程序，因为它们适用于病理大脑。最后，对基于体素的形态测量在AD研究中的应用前景进行了展望。(C)北京：科学出版社.
Up till now, the study of regional gray matter atrophy in Alzheimer's disease (AD) has been assessed with regions of interest, but this method is time-consuming, observer dependent, and poorly reproducible (especially in terms of cortical regions boundaries) and in addition is not suited to provide a comprehensive assessment of the brain. In this study, we have mapped gray matter density by means of voxel-based morphometry on Tl-weighted MRI volume sets in 19 patients with mild AD and 16 healthy subjects of similar age and gender ratio and report highly significant clusters of gray matter loss with almost symmetrical distribution, affecting mainly and in decreasing order of significance the medial temporal structures, the posterior cingulate gyrus and adjacent precuneus, and the temporoparietal association and perisylvian neocortex, with only little atrophy in the frontal lobe. The findings are discussed in light of previous studies of gray matter atrophy in AD based either on postmortem or neuroimaging data and in relation to PET studies of resting glucose consumption. The limitations of the method are also discussed in some detail, especially with respect to the segmentation and spatial normalization procedures as they apply to pathological brains. Some potential applications of voxel-based morphometry in the study of AD are also mentioned. (C) 2001 Academic Press.