THE RELATIONSHIP BETWEEN POWDER INHALER RESISTANCE AND PEAK INSPIRATORY CONDITIONS IN HEALTHY-VOLUNTEERS - IMPLICATIONS FOR IN-VITRO TESTING
THE RELATIONSHIP BETWEEN POWDER INHALER RESISTANCE AND PEAK INSPIRATORY CONDITIONS IN HEALTHY-VOLUNTEERS - IMPLICATIONS FOR IN-VITRO TESTING
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DOI：
10.1089/jam.1993.6.99
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发表时间：
1993-06-01
期刊：
影响因子：
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通讯作者：
HOLLINGWORTH, AM
中科院分区：
文献类型：
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作者：
CLARK, AR;HOLLINGWORTH, AM
尽管粉末吸入器装置已经可用了30多年，但是关于粉末吸入器设计如何与患者的气道动力学相互作用的基本信息仍然非常少。本文记录了旨在阐明这种相互作用的人类志愿者调查的结果。这些数据表明，如果采用“最大”吸入力，则通过吸入器获得的流速由胸部肌肉产生的最大压降控制。然而，如果使用中等或“舒适”的努力，关系是更复杂的。一个方程定义的“可吸入分数”的吸入气雾剂云作为吸入流量的函数也提出了。
Despite the fact that powder inhaler devices have been available for over 3 decades there is still very little fundamental information as to how powder inhaler design interacts with the airway dynamics of patients. This paper documents the results of human volunteer investigations designed to elucidate this interaction. These data indicates that if 'maximum' inhalation effort is employed the flow rate attained through an inhaler is controlled by the maximum pressure drop developed by the chest muscles. If a moderate or 'comfortable' effort is used, however, the relationship is more complex.An equation for defining the 'respirable fraction' of an inhalation aerosol cloud as a function of inhalation flow rate is also proposed.