The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium.
The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium.
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作者：
van Dam TJ;Wheway G;Slaats GG;SYSCILIA Study Group;Huynen MA;Giles RH
跨国SYSCILIA联盟的目标是从机制上了解纤毛。我们利用多个并行的高通量(HTP)计划来开发复杂的基因类型和不同的纤毛疾病表型之间的关系的预测模型。所生成的模型仅与输入的湿实验室数据一样好。因此，为了能够评估任何HTP数据集的质量，编排一个经过良好注释和高置信度的数据集是至关重要的。在这里，我们提出了作为公共资源的已知睫毛成分的首创SYSCILIA黄金标准。
The multinational SYSCILIA consortium aims to gain a mechanistic understanding of the cilium. We utilize multiple parallel high-throughput (HTP) initiatives to develop predictive models of relationships between complex genotypes and variable phenotypes of ciliopathies. The models generated are only as good as the wet laboratory data fed into them. It is therefore essential to orchestrate a well-annotated and high-confidence dataset to be able to assess the quality of any HTP dataset. Here, we present the inaugural SYSCILIA gold standard of known ciliary components as a public resource.