Highly attenuated smallpox vaccine protects rabbits and mice against pathogenic orthopoxvirus challenge
Highly attenuated smallpox vaccine protects rabbits and mice against pathogenic orthopoxvirus challenge
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DOI：
10.1016/j.vaccine.2005.03.029
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发表时间：
2006-04-24
期刊：
影响因子：
5.5
通讯作者：
Moyer, RW
中科院分区：
文献类型：
--
作者：
Empig, C;Kenner, JR;Moyer, RW
天花可能通过生物恐怖主义重新出现，需要准备充足的疫苗储备。Dryvax是唯一一种在美国获得许可的牛痘病毒天花疫苗，在活动前的设置中具有不可接受的安全性。LC16M8是一种日本许可的减毒痘苗病毒株，已在50,000多人中安全使用。到目前为止，这种疫苗的有效性还没有得到证实。使用两种动物模型，我们证明了LC16m8和Dryvax在单次接种后可以激发类似的体液免疫反应，并同等地预防致命的痘病毒病。因此，LC16m8有希望成为一种安全有效的天花疫苗，有可能取代Dryvax。(C)2006年，爱思唯尔有限公司出版。
The possible reemergence of smallpox through bioterrorism requires the preparation of adequate stockpiles of vaccine. Dryvax, the only US-licensed vaccinia virus smallpox vaccine, has an unacceptable safety profile in the pre-event setting. LC16m8 is a Japanese-licensed attenuated vaccinia virus strain that has been safely used in over 50,000 persons. Until now, efficacy of this vaccine was unproven. Using two animal models, we show that LC16m8 and Dryvax elicit comparable humoral immune responses after a single vaccination and equivalently protect against lethal poxvirus disease. Thus, LC16m8 shows promise as a safe and effective smallpox vaccine with the potential for replacing Dryvax. (c) 2006 Published by Elsevier Ltd.