Low-Dose Whole-Lung Irradiation for COVID-19 Pneumonia: Short Course Results
Low-Dose Whole-Lung Irradiation for COVID-19 Pneumonia: Short Course Results
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DOI：
10.1016/j.ijrobp.2020.07.026
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发表时间：
2020-12-01
影响因子：
7
通讯作者：
Taghizadeh-Hesary, Farzad
中科院分区：
文献类型：
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作者：
Ameri, Ahmad;Rahnama, Nazanin;Taghizadeh-Hesary, Farzad
目的：新冠肺炎疫情正在影响全球人民。许多受感染的患者有呼吸道感染，可能会发展为急性呼吸窘迫综合征。这项先导性研究旨在评估小剂量全肺放射治疗新冠肺炎肺炎的临床疗效。方法和材料：在伊朗进行的这项临床试验中，我们招募了60岁以上的新冠肺炎肺炎患者，他们因有记录的肺炎而需要补充氧气。受试者接受了全肺照射，每次0.5Gy加新冠肺炎的国家管理方案。记录照射前后的生命体征(包括血氧和体温)和实验室检查结果(白细胞介素6和C反应肽)。结果：2020年5月21日至2020年6月24日，5例患者接受了全肺照射。随访5~7d，评价治疗反应和毒性反应。5例患者中有4例(4例恶化，于第3天死亡)的临床和临床表现在照射后第1天有所改善。患者3在照射后第三天选择退出试验。其余3例患者平均出院时间为6天。结论：单次0.5Gy全肺照射治疗新冠肺炎肺炎氧依赖型患者疗效良好，有效率达80%。(C)2020 Elsevier Inc.保留所有权利。
Purpose: The COVID-19 outbreak is affecting people worldwide. Many infected patients have respiratory involvement that may progress to acute respiratory distress syndrome. This pilot study aimed to evaluate the clinical efficacy of low-dose whole-lung radiation therapy in patients with COVID-19 pneumonia.Methods and Materials: In this clinical trial, conducted in Iran, we enrolled patients with COVID-19 who were older than 60 years and hospitalized to receive supplementary oxygen for their documented pneumonia. Participants were treated with whole-lung irradiation in a single fraction of 0.5 Gy plus the national protocol for the management of COVID-19. Vital signs (including blood oxygenation and body temperature) and laboratory findings (interleukin-6 and C-reactive peptide) were recorded before and after irradiation.Results: Between May 21, 2020 and June 24, 2020, 5 patients received whole-lung irradiation. They were followed for 5 to 7 days to evaluate the response to treatment and toxicities. The clinical and paraclinical findings of 4 of the 5 patients (patient 4 worsened and died on day 3) improved on the first day of irradiation. Patient 3 opted out of the trial on the third day after irradiation. The mean time to discharge was 6 days for the other 3 patients. No acute radiation-induced toxicity was recorded.Conclusions: With a response rate of 80%, whole-lung irradiation in a single fraction of 0.5 Gy had encouraging results in oxygen-dependent patients with COVID-19 pneumonia. (C) 2020 Elsevier Inc. All rights reserved.