Facile installation of the phosphonate and (α,α-difluoromethyl)phosphonate functionalities equipped with benzyl protection
Facile installation of the phosphonate and (α,α-difluoromethyl)phosphonate functionalities equipped with benzyl protection
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DOI：
10.1016/s0040-4039(99)00077-5
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发表时间：
1999-03-05
影响因子：
1.8
通讯作者：
Peris, G
中科院分区：
文献类型：
--
作者：
Berkowitz, DB;Bhuniya, D;Peris, G
在适当的条件下，二(硫代甲基)膦酸二苄酯和二苄基(二硫代二氟甲基)膦酸根取代三氟代膦酸根，以方便地获得相应的膦酸根，并带有苄基酯保护基。这种方法对于磷酸酯去保护特别有利，这可以通过简单的氢解来实现。(C)1999爱思唯尔科学有限公司。保留所有权利。
Under appropriate conditions, dibenzyl (lithiomethyl)phosphonate and dibenzyl (lithiodifluoromethyl)phosphonate displace primary triflates to provide convenient access to the corresponding phosphonates, carrying benzyl ester protecting groups. This approach is of particular advantage for phosphonate ester deprotection, which may be achieved by simple hydrogenolysis. (C) 1999 Elsevier Science Ltd. All rights reserved.