INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects
INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects
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DOI：
10.1038/sj.ijo.0803645
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发表时间：
2007-11-01
影响因子：
4.9
通讯作者：
Humphries, S. E.
中科院分区：
文献类型：
--
作者：
Smith, A. J. P.;Cooper, J. A.;Humphries, S. E.
胰岛素诱导基因2转录起始点上游10kb的一个常见的多态rs7566605与高加索人和非裔美国人的肥胖有关，假设基因表达的变化会导致血浆甘油三酯水平升高。这项研究的目的是验证2721名健康的高加索男性队列中的发现(第二项诺斯威克公园心脏研究)，以及一项针对747名来自高加索、非洲加勒比和印度人群的2型糖尿病患者的单独研究(伦敦大学学院糖尿病和心血管疾病研究)。在这两项研究中，rs7566605单核苷酸多态(SNP)与血浆甘油三酯水平均无关联，尽管有能力检测到先前报道的影响，但我们在这两个队列中均未发现与体重指数或肥胖的关联。这表明，至少，这种SNP对肥胖的真正影响可能比之前报道的要小得多。
A common polymorphism, rs7566605, 10 kb upstream of the insulin-induced gene 2 transcription start site has been associated with obesity in Caucasian and African-American populations, with the hypothesis that an alteration in gene expression results in elevated plasma triglyceride levels. The goal of this study was to verify the findings in a cohort of 2721 healthy Caucasian men (second Northwick Park Heart Study), and a separate study of 747 type 2 diabetic patients from Caucasian, Afro-Caribbean and Indian groups (University College London Diabetes and Cardiovascular Disease Study). The rs7566605 single-nucleotide polymorphism (SNP) was not related to plasma triglyceride levels in either study, and we found no association with body mass index or obesity in either cohort, despite having the power to detect the previously reported effect. This suggests that, at the least, the true size of the effect on obesity of this SNP is likely to be considerably less than reported previously.