Multicomponent assembly strategies for the synthesis of diverse tetrahydroisoquinoline scaffolds.
Multicomponent assembly strategies for the synthesis of diverse tetrahydroisoquinoline scaffolds.
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DOI：
10.1021/ol201739u
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发表时间：
2011-09-02
期刊：
影响因子：
5.2
通讯作者：
Martin SF
中科院分区：
文献类型：
--
作者：
Granger BA;Kaneda K;Martin SF
已经开发了几种新的多组分组装方法，用于快速有效地组装具有四氢异喹啉核心的各种杂环支架，其中每一种都允许容易的衍生化以获得各种各样的化合物。本工作意外地发现了一种合成稠合喹唑啉酮环体系的新方法，并将其应用于喹唑啉咔啉生物碱吴茱萸次碱的一步全合成。
Several novel multicomponent assembly processes have been developed for the rapid and efficient assembly of various heterocyclic scaffolds bearing a tetrahydroisoquinoline core, each of which allows for facile derivatization to access a diverse array of compounds. This work led to the serendipitous discovery of a new method for the synthesis of a fused quinazolone ring system, which was applied to a one-step total synthesis of the quinazolinocarboline alkaloid rutaecarpine.