Phylogenetic assessment of filoviruses: how many lineages of Marburg virus?
Phylogenetic assessment of filoviruses: how many lineages of Marburg virus?
复制标题
DOI：
10.1002/ece3.297
复制
发表时间：
2012-08-01
影响因子：
2.6
通讯作者：
Holder, Mark T.
中科院分区：
文献类型：
--
作者：
Peterson, A. Townsend;Holder, Mark T.
迄今为止，丝状病毒被认为由一种不同的属（埃博拉病毒）和一种未分化的属（马尔堡病毒）组成。我们通过对丝状病毒科可用序列数据进行详细的系统发育分析来重新考虑这个想法：使用聚结模拟，我们确定两个马尔堡分离株（称为“RAVN”菌株）代表了一个相当独特的谱系，在生物地理学和宿主关联性的研究中应该考虑到这一谱系，并且可能值得在物种水平上得到认可。相比之下，最近从蝙蝠组织中获得的丝状病毒分离株与之前已知的毒株没有区别，应被视为来自同一种群。讨论了了解这些病毒的传播地理和宿主关联的意义。
Filoviruses have to date been considered as consisting of one diverse genus (Ebola viruses) and one undifferentiated genus (Marburg virus). We reconsider this idea by means of detailed phylogenetic analyses of sequence data available for the Filoviridae: using coalescent simulations, we ascertain that two Marburg isolates (termed the "RAVN" strain) represent a quite-distinct lineage that should be considered in studies of biogeography and host associations, and may merit recognition at the level of species. In contrast, filovirus isolates recently obtained from bat tissues are not distinct from previously known strains, and should be considered as drawn from the same population. Implications for understanding the transmission geography and host associations of these viruses are discussed.