Coordinated and Compartmentalized Neuromodulation Shapes Sensory Processing in Drosophila.
Coordinated and Compartmentalized Neuromodulation Shapes Sensory Processing in Drosophila.
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DOI：
10.1016/j.cell.2015.11.019
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发表时间：
2015-12-17
期刊：
影响因子：
64.5
通讯作者：
Ruta V
中科院分区：
文献类型：
--
作者：
Cohn R;Morantte I;Ruta V
学习和适应行为依赖于神经回路，这些神经回路将相同的感官输入灵活地耦合到替代的输出路径。在这里，我们表明果蝇蘑菇体的功能就像一个开关板，神经调节将相同的气味信号重新路由到不同的行为电路，这取决于果蝇的状态和经验。使用功能性突触成像和电生理学，我们发现，多巴胺能输入到蘑菇体调制突触传递与精致的空间特异性，允许个别神经元差异传递嗅觉信号到每个他们的突触后目标。此外，我们表明多巴胺能神经元作为一个相互连接的网络发挥作用，编码有关动物外部环境和内部状态的信息，以协调整个蘑菇体的突触可塑性。我们的数据表明，行为灵活性的一般电路机制，其中神经调节网络与突触精度的行为，将一个单一的感觉输入到不同的输出活动模式。
Learned and adaptive behaviors rely on neural circuits that flexibly couple the same sensory input to alternative output pathways. Here, we show that the Drosophila mushroom body functions like a switchboard in which neuromodulation reroutes the same odor signal to different behavioral circuits, depending on the state and experience of the fly. Using functional synaptic imaging and electrophysiology, we reveal that dopaminergic inputs to the mushroom body modulate synaptic transmission with exquisite spatial specificity, allowing individual neurons to differentially convey olfactory signals to each of their postsynaptic targets. Moreover, we show that the dopaminergic neurons function as an interconnected network, encoding information about both an animal's external context and internal state to coordinate synaptic plasticity throughout the mushroom body. Our data suggest a general circuit mechanism for behavioral flexibility in which neuromodulatory networks act with synaptic precision to transform a single sensory input into different patterns of output activity.