Dissecting contributions of prefrontal cortex and fusiform face area to face working memory
Dissecting contributions of prefrontal cortex and fusiform face area to face working memory
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DOI：
10.1162/089892903322370708
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发表时间：
2003-08-15
影响因子：
3.2
通讯作者：
D'Esposito, M
中科院分区：
文献类型：
--
作者：
Druzgal, TJ;D'Esposito, M
假设前额叶皮层（PFC）和刺激特异性视觉皮层关联区之间的相互作用介导行为猴的视觉工作记忆。为了明确人类中同源区域的作用，使用事件相关功能磁共振成像来评估执行面部延迟识别任务的受试者PFC和梭状面区（FFA）的神经活动。在PFC和FFA中，尽管激活程度在数量上存在差异，但在面部刺激的编码和维持过程中，活动随着记忆负荷的增加而参数化地增加。此外，在记忆编码和检索过程中，PFC和FFA激活的时间差异暗示了神经信息流的情境依赖性。这些结果支持现有的非人类灵长类动物视觉工作记忆的神经生理学模型。
Interactions between prefrontal cortex (PFC) and stimulus-specific visual cortical association areas are hypothesized to mediate visual working memory in behaving monkeys. To clarify the roles for homologous regions in humans, event-related fMRI was used to assess neural activity in PFC and fusiform face area (FFA) of subjects performing a delay-recognition task for faces. In both PFC and FFA, activity increased parametrically with memory load during encoding and maintenance Of face Stimuli,, despite quantitative differences in the magnitude of activation. Moreover, timing differences in PFC and FFA activation during Memory encoding and retrieval implied a context dependence in the flow of neural information. These results support existing neurophysiological models of visual working memory developed in the nonhuman primate.