Corticotropin-releasing factor and the psychobiology of early-life stress
Corticotropin-releasing factor and the psychobiology of early-life stress
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DOI：
10.1111/j.1467-8721.2007.00481.x
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发表时间：
2007-04-01
影响因子：
7.2
通讯作者：
Nemeroff, Charles B.
中科院分区：
文献类型：
--
作者：
Gillespie, Charles F.;Nemeroff, Charles B.
童年时期的创伤和忽视越来越被认为是成人情绪和焦虑症的病因学因素。关于压力生物学在早期不良经历对成人精神病理学的持续影响中的作用，人们已经了解了很多。在这里，我们提出了一个发展性创伤的抑郁症和焦虑的心理生物学的概述。我们强调促肾上腺皮质激素释放因子在这些疾病的病理生理学中的作用，重点是早期生活创伤到成人精神病理学的转导。
Trauma and neglect during childhood are increasingly appreciated as factors in the etiology of adult mood and anxiety disorders. Much has been learned about the role of stress biology in the persisting effects of early adverse experience on adult psychopathology. Here we present an overview of developmental trauma in the psychobiology of depression and anxiety. We emphasize the role of corticotropin-releasing factor in the pathophysiology of these disorders, focusing on the transduction of early life trauma into adult psychopathology.