The adverse effects of long-term l-carnitine supplementation on liver and kidney function in rats
The adverse effects of long-term l-carnitine supplementation on liver and kidney function in rats
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DOI：
10.1177/0960327115571767
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发表时间：
2015-11-01
影响因子：
2.8
通讯作者：
Kong, L-D
中科院分区：
文献类型：
--
作者：
Liu, L.;Zhang, D-M;Kong, L-D
左旋肉碱（左旋肉碱）广泛应用于健康和食品。本研究的重点是在雌性和雄性Sprague道利大鼠中口服补充左旋肉碱（0.3和0.6 g/kg）8周后的不良反应。左旋肉碱降低大鼠的体重和脂肪重量，以及血清、肝脏和肾脏的脂质水平。同时，肝脏脂肪酸氧化和脂质合成的干扰，在左旋肉碱喂养大鼠。此外，L-肉毒碱加速血清和肝脏中活性氧的产生，从而触发肝脏NOD样受体3（NLRP 3）炎性小体激活，以升高大鼠血清白细胞介素（IL）-1和IL-18水平。血清碱性磷酸酶水平的改变进一步证实了左卡尼汀喂养大鼠的肝功能障碍。此外，左旋卡尼汀可能通过改变大鼠有机离子转运蛋白的肾脏蛋白水平而潜在地干扰肾功能。这些观察结果可能为长期补充左旋肉碱的安全性提供警示信息。
Levo-Carnitine (l-carnitine) is widely used in health and food. This study was to focus on the adverse effects of 8-week oral supplementation of l-carnitine (0.3 and 0.6 g/kg) in female and male Sprague Dawley rats. l-carnitine reduced body and fat weights, as well as serum, liver, and kidney lipid levels in rats. Simultaneously, hepatic fatty acid -oxidation and lipid synthesis were disturbed in l-carnitine-fed rats. Moreover, l-carnitine accelerated reactive oxygen species production in serum and liver, thereby triggering hepatic NOD-like receptor 3 (NLRP3) inflammasome activation to elevate serum interleukin (IL)-1 and IL-18 levels in rats. Alteration of serum alkaline phosphatase levels further confirmed liver dysfunction in l-carnitine-fed rats. Additionally, l-carnitine may potentially disturb kidney function by altering renal protein levels of rat organic ion transporters. These observations may provide the caution information for the safety of long-term l-carnitine supplementation.