Exploring Associations Between a Biological Marker of Chronic Stress and Reported Depression and Anxiety in People With Aphasia.
Exploring Associations Between a Biological Marker of Chronic Stress and Reported Depression and Anxiety in People With Aphasia.
复制标题
探索失语症患者慢性压力的生物标志物与抑郁和焦虑之间的关联。
DOI：
10.1044/2019_jslhr-l-19-0111
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Kendall,Diane
中科院分区：
文献类型：
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作者：
Pompon,RebeccaHunting;Smith,AlissaN;Baylor,Carolyn;Kendall,Diane
目的失语症的沟通障碍会给生活带来压力。慢性压力、抑郁和焦虑密切相关，可能在卒中后失语症患者中比一般人群更普遍，并可能影响认知功能和治疗结果。在这个项目中，我们探讨了心理结构的抑郁症和焦虑症及其协会的生物标志物措施的慢性压力的人与aphasia.Methodfifty-seven参与者与失语症完成的措施抑郁症和焦虑症，并提供了头发样本，从中提取的压力激素皮质醇。Pearson积差相关分析被用来确定抑郁症，焦虑症，和长期水平的皮质醇之间的关联通过hair samples.ResultsWhile皮质醇水平是不相关的抑郁症和焦虑症在这个样本的人与失语症，事后分析显示，一个显着的，正相关的一个子集的参与者与中度和较高水平的抑郁症和皮质醇水平升高。迄今为止，在失语症患者中很少探索抑郁和焦虑，但它们与未来的健康后果和认知功能受损有关，这激发了进一步的研究，并在失语症康复中考虑这些因素。
PurposeLiving with the communication impairment of aphasia can be stressful. Chronic stress, depression, and anxiety are intimately linked, may be more pervasive in people with poststroke aphasia than the general population, and may influence cognitive function and treatment outcomes. In this project, we explored the psychological constructs of depression and anxiety and their associations with a biomarker measure of chronic stress in people with aphasia.MethodFifty-seven participants with aphasia completed measures of depression and anxiety and provided a hair sample from which to extract the stress hormone cortisol. Pearson product–moment correlational analyses were used to identify associations between depression, anxiety, and long-term level of cortisol via hair sample.ResultsWhile cortisol level was not associated with depression and anxiety across this sample of people with aphasia, a post hoc analysis showed a significant, positive correlation between a subset of participants with moderate and higher levels of depression and elevated cortisol level.ConclusionsChronic stress, depression, and anxiety have been little explored in people with aphasia to date, yet they are associated with future health consequences and impaired cognitive function, motivating further research as well as consideration of these factors in aphasia rehabilitation.