Adding functionality with additive manufacturing: Fabrication of titanium-based antibiotic eluting implants
Adding functionality with additive manufacturing: Fabrication of titanium-based antibiotic eluting implants
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DOI：
10.1016/j.msec.2016.04.006
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发表时间：
2016-07-01
影响因子：
7.9
通讯作者：
Grover, Liam M.
中科院分区：
文献类型：
--
作者：
Cox, Sophie C.;Jamshidi, Parastoo;Grover, Liam M.
增材制造技术已被用于医疗保健领域，以制造针对患者的植入物。这项研究表明，通过进一步利用这些技术的设计灵活性，可以增加新的植入物功能。采用选择性激光熔融法制备钛基（Ti-6A1-4V）植入物。将种植体表面与储存库连接的孔通道被纳入，以促进抗生素的输送。配制了一种可注射的刷石磷酸钙水泥作为庆大霉素的载体。与非抗生素样品相比，抗生素的掺入显著（p = 0.01）提高了水泥的抗压强度（5.8 +/- 0.7 MPa）。用紫外可见光谱法对注入种植体储存库的磷酸钙水泥进行了短期洗脱研究，证实了硫酸庆大霉素的控释。利用微型计算机断层扫描显示了植入物孔隙通道的方向，以影响设计的可重复性和水泥注入过程中产生的背压，最终改变了孔隙度。所有植入物在6小时内释放的抗生素量(
Additive manufacturing technologies have been utilised in healthcare to create patient-specific implants. This study demonstrates the potential to add new implant functionality by further exploiting the design flexibility of these technologies. Selective laser melting was used to manufacture titanium-based (Ti-6A1-4V) implants containing a reservoir. Pore channels, connecting the implant surface to the reservoir, were incorporated to facilitate antibiotic delivery.An injectable brushite, calcium phosphate cement, was formulated as a carrier vehicle for gentamicin. Incorporation of the antibiotic significantly (p = 0.01) improved the compressive strength (5.8 +/- 0.7 MPa) of the cement compared to non-antibiotic samples. The controlled release of gentamicin sulphate from the calcium phosphate cement injected into the implant reservoir was demonstrated in short term elution studies using ultraviolet visible spectroscopy. Orientation of the implant pore channels were shown, using micro-computed tomography, to impact design reproducibility and the back-pressure generated during cement injection which ultimately altered porosity. The amount of antibiotic released from all implant designs over a 6 hour period (