Cell-intrinsic signals that regulate adult neurogenesis in vivo: insights from inducible approaches.
Cell-intrinsic signals that regulate adult neurogenesis in vivo: insights from inducible approaches.
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DOI：
10.5483/bmbrep.2009.42.5.245
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发表时间：
2009-05-31
期刊：
影响因子：
3.8
通讯作者：
Eisch AJ
中科院分区：
文献类型：
--
作者：
Johnson MA;Ables JL;Eisch AJ
成体神经干细胞在成年哺乳动物大脑中产生新的、功能完整的神经元的过程已经得到了深入的研究，但还有更多的东西有待发现。众所周知，神经前体细胞经过不同的阶段发展成为成熟的神经元，这一过程受到神经源性缝隙中细胞-细胞相互作用和信号的严格控制。然而，对于成人神经发生阶段的正常发展所需的细胞内在信号却知之甚少。最近已经开发出在体内操纵成年神经干细胞和祖细胞中的基因的技术，例如使用可诱导的转基因小鼠和病毒介导的基因转导。利用这些技术的出版物已经达到了临界量，这使得现在及时审查哪些分子现在已知在体内调节成人神经发生的细胞内在作用。通过引起人们对这些孤立分子(如Notch)的注意，我们希望能刺激更广泛的努力，以了解对成人神经发生重要的内在信号分子的复杂和引人注目的级联。了解这一过程为了解神经发生所辅助的大脑功能，如记忆，以及利用神经干细胞修复患病和受伤的大脑提供了可能性。
The process by which adult neural stem cells generate new and functionally integrated neurons in the adult mammalian brain has been intensely studied, but much more remains to be discovered. It is known that neural progenitors progress through distinct stages to become mature neurons, and this progression is tightly controlled by cell-cell interactions and signals in the neurogenic niche. However, less is known about the cell-intrinsic signaling required for proper progression through stages of adult neurogenesis. Techniques have recently been developed to manipulate genes specifically in adult neural stem cells and progenitors in vivo, such as the use of inducible transgenic mice and viral-mediated gene transduction. A critical mass of publications utilizing these techniques has been reached, making it timely to review which molecules are now known to play a cell-intrinsic role in regulating adult neurogenesis in vivo. By drawing attention to these isolated molecules (e.g. Notch), we hope to stimulate a broad effort to understand the complex and compelling cascades of intrinsic signaling molecules important to adult neurogenesis. Understanding this process opens the possibility of understanding brain functions subserved by neurogenesis, such as memory, and also of harnessing neural stem cells for repair of the diseased and injured brain.
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影响因子：
5.3
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.0804558105
发表时间：
2008-09-02
影响因子：
11.1
作者：
Breunig, Joshua J.;Sarkisian, Matthew R.;Town, Terrence
通讯作者：
Town, Terrence