Hippocampal Subfield Volumetry: Differential Pattern of Atrophy in Different Forms of Genetic Frontotemporal Dementia.
Hippocampal Subfield Volumetry: Differential Pattern of Atrophy in Different Forms of Genetic Frontotemporal Dementia.
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DOI：
10.3233/jad-180195
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Rohrer JD
中科院分区：
文献类型：
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作者：
Bocchetta M;Iglesias JE;Scelsi MA;Cash DM;Cardoso MJ;Modat M;Altmann A;Ourselin S;Warren JD;Rohrer JD
额颞叶痴呆（FTD）是一种异质性神经退行性疾病，具有很强的遗传成分。先前的研究表明内侧颞叶萎缩是FTD的共同特征。然而，迄今为止尚未有研究调查海马亚区在FTD中的不同易感性。我们的目的是研究遗传性FTD的海马亚区体积。我们于2018年6月2日研究了75例遗传性FTD患者的海马亚区体积(年龄：平均（标准差）59.3（7.7）岁；病程：5.1（3.4）年；29人患有MAPT， 28人患有C9orf72, 18人患有GRN突变)，而97名年龄匹配的对照组（年龄：62.1（11.1）岁）。我们对他们的体积t1加权MRI扫描进行分割，以提取海马亚区体积。左、右容积相加并校正为颅内总容积。所有三组的海马体都比对照组小。MAPT组海马萎缩最严重，子区与对照组差异最大的是CA1-4 （24-27%, p < 0.0005）。对于C9orf72， CA4， CA1和齿状回区（8-11%,p < 0.0005），对于GRN，骨下前和骨下区（10-14%,p < 0.0005）与对照组差异最大。海马体在所有突变类型中都受到影响，但在三个遗传组中发现了不同的子野受累模式，这与不同的皮层-皮层下网络脆弱性相一致。
Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder, with a strong genetic component. Previous research has shown that medial temporal lobe atrophy is a common feature of FTD. However, no study has so far investigated the differential vulnerability of the hippocampal subfields in FTD. We aimed to investigate hippocampal subfield volumes in genetic FTD. We in6/2/2018vestigated hippocampal subfield volumes in a cohort of 75 patients with genetic FTD (age: mean (standard deviation) 59.3 (7.7) years; disease duration: 5.1 (3.4) years; 29 with MAPT, 28 with C9orf72, and 18 with GRN mutations) compared with 97 age-matched controls (age: 62.1 (11.1) years). We performed a segmentation of their volumetric T1-weighted MRI scans to extract hippocampal subfields volumes. Left and right volumes were summed and corrected for total intracranial volumes. All three groups had smaller hippocampi than controls. The MAPT group had the most atrophic hippocampi, with the subfields showing the largest difference from controls being CA1-4 (24–27%, p < 0.0005). For C9orf72, the CA4, CA1, and dentate gyrus regions (8–11%, p < 0.0005), and for GRN the presubiculum and subiculum (10–14%, p < 0.0005) showed the largest differences from controls. The hippocampus was affected in all mutation types but a different pattern of subfield involvement was found in the three genetic groups, consistent with differential cortical-subcortical network vulnerability.