Long-term association of cardiovascular risk factors with impaired insulin secretion and insulin resistance
Long-term association of cardiovascular risk factors with impaired insulin secretion and insulin resistance
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DOI：
10.1053/meta.2000.9514
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发表时间：
2000-10-01
影响因子：
9.8
通讯作者：
Laakso, M
中科院分区：
文献类型：
--
作者：
Kekäläinen, P;Sarlund, H;Laakso, M
本研究的目的是在非糖尿病受试者中进行一项为期8年的前瞻性人群研究，以探讨心血管危险因素与胰岛素抵抗和胰岛素分泌受损的关系。在基线时测量271名年龄在16至61岁的受试者的心血管危险因素，8年后通过静脉葡萄糖耐量试验（IVGTT）和Bergman最小模型评估胰岛素敏感性和急性时相胰岛素分泌。在logistic回归分析中，基线高密度脂蛋白（HDL）和极低密度脂蛋白（VLDL）胆固醇（分别为P <0.001和P = 0.006）、总甘油三酯、低密度脂蛋白（LDL）甘油三酯和极低密度脂蛋白甘油三酯经年龄和体重指数（BMI）校正后，胰岛素抵抗与载脂蛋白A1（P = 0.010）和尿酸（P <0.001）相关（分别为P = 0.004、P = 0.048和P = 0.002）。在校正年龄和BMI后，收缩压（P = 0.042）和VLDL胆固醇（P = 0.018）与胰岛素分泌受损相关。这项为期8年的纵向研究表明，血脂异常、高血压和尿酸与胰岛素抵抗相关，而高收缩压和VLDL胆固醇与第一时相胰岛素分泌受损相关。Copyright（C）2000 by W.B.桑德斯公司
The study aim was to investigate the association of cardiovascular risk factors with insulin resistance and impaired insulin secretion in an 8-year prospective population study in nondiabetic subjects. Cardiovascular risk factors of 271 subjects aged 16 to 61 years were measured at baseline, and insulin sensitivity and acute-phase insulin secretion were assessed by an intravenous glucose tolerance test (IVGTT) and Bergman's minimal model 8 years later. In logistic regression analysis, baseline high-density lipoprotein (HDL) and very-low-density lipoprotein (VLDL) cholesterol (P < .001 and P = .006, respectively), total, low-density lipoprotein (LDL), and VLDL triglycerides (P = .004, P = .048, and P = .002, respectively), apolipoprotein Al (P = .010), and uric acid (P < .001) were associated with insulin resistance after adjustment for age and the body mass index (BMI). Systolic brood pressure(P = .042) and VLDL cholesterol(P = .018) were associated with impaired insulin secretion after adjustment for age and the BMI. This 8-year longitudinal study demonstrates that dyslipidemia, high blood pressure, and uric acid are associated with insulin resistance, whereas high systolic blood pressure and VLDL cholesterol are associated with impaired first-phase insulin secretion. Copyright (C) 2000 by W.B. Saunders Company.