RADIATION RESISTANCE WITH AGE IN NORMAL AND IRRADIATED POPULATIONS OF MICE.
RADIATION RESISTANCE WITH AGE IN NORMAL AND IRRADIATED POPULATIONS OF MICE.
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正常和受辐射小鼠群体的辐射抗性随年龄的变化。
DOI：
10.2307/3571760
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发表时间：
1965
影响因子：
3.4
通讯作者：
J. Storer
中科院分区：
文献类型：
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作者：
J. Storer
这些考虑也适用于估计受照射人群在初次照射后很长时间内的残余辐射损伤的问题。在这种情况下，残余辐射损伤是指不可修复的损伤的组成部分，在急性损伤和初次照射后的恢复阶段之后，这种损伤可以被检测为对进一步照射的急性致死效应的敏感性增加（6-11）。这种损伤的程度通常通过经典的“分次剂量”技术来测量（6）。根据该技术中使用的假设和定义，残余损伤通常占初始暴露后总损伤的约5 - 10%（90 - 95%的损伤得到修复）。人们通常认为，在动物的整个剩余寿命中，残余损伤的水平保持不变，但实验数据并不完全足以支持这一假设。Sacher和Grahn（12）推导出的脉冲致死率函数表明，在单次接触后，整个生命期内的损伤水平下降得越来越慢。该函数基于以下方法获得的数据：
These considerations also apply to the problem of estimating residual radiation injury in irradiated populations at long times after the initial exposure. In this context, residual radiation injury refers to that component of irreparable injury that can be detected as an increased sensitivity to the acute lethal effects of further radiation exposure at times beyond the phase of acute injury and recovery after the initial exposure (6-11). The extent of this injury is usually measured by the classical "split-dose" technique (6). On the basis of the assumptions and definitions utilized in this technique, residual injury usually amounts to about 5 to 10% of the total injury sustained after the initial exposure (90 to 95% of the injury is repaired). It is often assumed that the level of residual injury remains constant throughout the remaining life of the animal, but experimental data are not entirely adequate to support this assumption. The derived impulse lethality function of Sacher and Grahn (12) suggests an ever more slowly decreasing level of injury throughout life after a single exposure. This function is based on data obtained by