Function and specificity of 14-3-3 proteins in the regulation of carbohydrate and nitrogen metabolism
Function and specificity of 14-3-3 proteins in the regulation of carbohydrate and nitrogen metabolism
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DOI：
10.1093/jxb/erg057
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发表时间：
2003-01-01
影响因子：
6.9
通讯作者：
Martin, T
中科院分区：
文献类型：
--
作者：
Comparot, S;Lingiah, G;Martin, T
蛋白质磷酸化是调节许多蛋白质的关键。改变的蛋白质活性通常需要磷酸化的蛋白质与一类称为14-3-3蛋白质的“接头”相互作用。本文综述了14-3-3与硝酸还原酶、谷氨酰胺合成酶、蔗糖磷酸合成酶等碳氮代谢关键蛋白的相互作用。它还将解决14-3-3参与信号转导途径，重点是调节植物代谢。迄今为止，14-3-3蛋白已在许多不同的系统中被鉴定和研究，产生了大量的数据，需要仔细分析和解释。在处理多基因家族时，诸如此类的问题并不少见。同种型的数量使得14-3-3蛋白的冗余与特异性的问题成为关键问题。本文就14-3-3蛋白的结构、功能和表达等方面进行了讨论。
Protein phosphorylation is key to the regulation of many proteins. Altered protein activity often requires the interaction of the phosphorylated protein with a class of 'adapters' known as 14-3-3 proteins. This review will cover aspects of 14-3-3 interaction with key proteins of carbon and nitrogen metabolism such as nitrate reductase, glutamine synthetase and sucrose-phosphate synthase. It will also address 14-3-3 involvement in signal transduction pathways with emphasis on the regulation of plant metabolism. To date, 14-3-3 proteins have been identified and studied in many diverse systems, yielding a plethora of data, requiring careful analysis and interpretation. Problems such as these are not uncommon when dealing with multigene families. The number of isoforms makes the question of redundancy versus specificity of 14-3-3 proteins a crucial one. This issue is discussed in relation to structure, function and expression of 14-3-3 proteins.