The interrelation of age. immune response, and susceptibility to mumps virus in hamsters.
The interrelation of age. immune response, and susceptibility to mumps virus in hamsters.
复制标题
年龄的相互关系。
DOI：
10.4049/jimmunol.71.5.352
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发表时间：
1953
影响因子：
4.4
通讯作者：
L. Kilham
中科院分区：
文献类型：
--
作者：
J. Overman;L. Kilham
在不同年龄接种的仓鼠中，对腮腺炎病毒生长和抗体应答进行了直接比较。接种病毒不会引起明显疾病的仓鼠，比腮腺炎病毒引起致命脑炎的年轻仓鼠更早产生抗体，而且产生的抗体量相对更大。如果潜伏期缩短，老年仓鼠容易感染腮腺炎病毒，从而在建立高血清抗体水平之前死亡。
Direct comparison of mumps virus growth and antibody response has been made in hamsters inoculated at various ages. Hamsters, of an age at which inoculation of virus does not cause apparent disease, produce antibody earlier and in relatively greater amounts than do younger hamsters in which the mumps virus causes a fatal encephalitis. Older hamsters are susceptible to mumps virus if the incubation period is shortened so that death occurs before high serum antibody levels are established.