Soluble fibers from psyllium improve glycemic response and body weight among diabetes type 2 patients (randomized control trial)
Soluble fibers from psyllium improve glycemic response and body weight among diabetes type 2 patients (randomized control trial)
复制标题
DOI：
10.1186/s12937-016-0207-4
复制
发表时间：
2016-10-12
影响因子：
5.4
通讯作者：
Hamed, Amin T.
中科院分区：
文献类型：
--
作者：
Abutair, Ayman S.;Naser, Ihab A.;Hamed, Amin T.
背景资料：水溶性膳食纤维的摄入可能有助于控制血糖和体重。目的：本研究的目的是确定从车前子中补充可溶性纤维是否能改善2型糖尿病患者的血糖控制指标和体重。方法：将40例年龄>35岁、不吸烟的2型糖尿病患者按性别、年龄、体重指数（BMI）和空腹血糖水平（FBS），并随机分为两组，干预组20例，给予可溶性纤维（每天10.5克），而由20名参与者组成的对照组继续正常饮食，持续8周。干预8周后，与对照组相比，补充可溶性纤维显示干预组的BMI显著降低（p < 0.001）。此外，水溶性纤维补充剂被证明可以改善FBS（163至119 mg/dl），HbA 1c（8.5至7.5%），胰岛素水平（27.9至19.7 mu IU/mL），C肽（5.8至3.8 ng/ml），HOMA。IR（11.3 - 5.8）和HOMA-β %（103 - 141%）。结论：在正常饮食中加入可溶性纤维可增强血糖反应的降低。食用含有适量这些纤维的食物可以改善2型糖尿病患者的葡萄糖代谢和血脂。
Background: Water-soluble dietary fibers intake may help control blood glucose and body weight.Objective: The objective of the study was to determine whether soluble fiber supplementation from psyllium improves glycemic control indicators and body weight in type 2 diabetic patients.Method: Forty type 2 diabetes patients, non-smoker, aged >35 years were stratified to different strata according to sex, age, body mass index (BMI) and fasting blood sugar level (FBS) and randomly assigned into two groups; The intervention group which consists of 20 participants was on soluble fiber (10.5 g daily), and the control group which consist of 20 participants continued on their regular diet for eight weeks duration.Results: After 8 weeks of intervention, soluble fiber supplementation showed significant reduction in the intervention group in BMI (p < 0.001) when compared with the control group. Moreover, water soluble fiber supplementation proven to improve FBS (163 to 119 mg/dl), HbA1c (8.5 to 7.5 %), insulin level (27.9 to 19.7 mu IU/mL), C-peptide (5.8 to 3.8 ng/ml), HOMA. IR (11.3 to 5.8) and HOMA-beta % (103 to 141 %).Conclusion: The reduction in glycemic response was enhanced by combining soluble fiber to the normal diet. Consumption of foods containing moderate amounts of these fibers may improve glucose metabolism and lipid profile in type 2 diabetes patients.