Characterizing the Link Between Glial Activation and Changed Functional Connectivity in National Football League Players Using Multimodal Neuroimaging.
Characterizing the Link Between Glial Activation and Changed Functional Connectivity in National Football League Players Using Multimodal Neuroimaging.
复制标题
使用多模态神经影像学表征国家橄榄球联盟球员中神经胶质激活和功能连接变化之间的联系。
DOI：
10.1176/appi.neuropsych.18110274
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Sair,HarisI
中科院分区：
文献类型：
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作者：
Peters,MatthewE;Rahman,Saudur;Coughlin,JenniferM;Pomper,MartinG;Sair,HarisI
这项初步研究的主要目的是研究NFL比赛对两个大脑区域之间的区域间功能连接的影响，即边缘上回（SMG）和丘脑，被确定为在NFL球员中具有较高的[11 C]DPA-713结合。作者的第二个目标是检查的影响，因为多年来发挥区域间connections.MethodsResting-state功能磁共振成像被用来检查区域之间的功能变化的证据，过去的伤害，在活跃或最近退役的NFL球员（定义为≤12年，因为NFL发挥）和遥远的退休球员（定义为>12年，因为NFL发挥）。与健康对照组相比，NFL球员表现出左SMG和双侧丘脑之间的联系丧失（平均z得分=-2.434，p=0.015）。检查右侧SMG连接时未观察到差异。在积极和最近退役的球员的连接模式模仿的模式观察到在遥远的退休球员和老年对照subjects.Conclusionsfurther研究的临床意义，这种改变的模式，区域间的连接在积极和最近退役的NFL球员是必要的。
ObjectiveThe primary objective of this preliminary study was to examine the impact of NFL play on interregional functional connectivity between two brain regions, the supramarginal gyrus (SMG) and the thalamus, identified as having higher binding of [11C]DPA-713 in NFL players. The authors’ secondary objective was to examine the effect of years since play on the interregional connectivity.MethodsResting-state functional MRI was used to examine functional brain changes between regions with evidence of past injury in active or recently retired NFL players (defined as ≤12 years since NFL play) and distantly retired players (defined as >12 years since NFL play). Age-comparable individuals without a history of concussion or participation in collegiate or professional collision sports were included as a control group.ResultsCompared with healthy control subjects, NFL players showed a loss of anticorrelation between the left SMG and bilateral thalami (mean z score=−2.434, p=0.015). No difference was observed when examining right SMG connectivity. The pattern of connectivity in active and recently retired players mimicked the pattern observed in distantly retired players and older control subjects.ConclusionsFurther study of the clinical significance of this altered pattern of interregional connectivity in active and recently retired NFL players is needed.