The effect of chronic prepubertal administration of marihuana (delta-9-tetrahydrocannabinol) on the onset of puberty and the postpubertal reproductive functions in female rats.
The effect of chronic prepubertal administration of marihuana (delta-9-tetrahydrocannabinol) on the onset of puberty and the postpubertal reproductive functions in female rats.
复制标题
青春期前长期服用大麻（δ9-四氢大麻酚）对雌性大鼠青春期开始和青春期后生殖功能的影响。
作者：
Tibor Wenger;Dominique Croix;G. Tramu
研究了大麻的主要精神活性成分--β-9-四氢大麻酚(THC)对雌性大鼠青春期发育期及出生后第75~80天生殖功能的影响。这种药物是ip..。剂量为1微克/公斤/天，从出生后第22天到阴道开放之日(V.O.)。给药组大鼠VO延迟2d，发情当天卵数显著低于对照组。青春期后持续至成年期的THC组动物神经内分泌功能发生改变：动情周期不规则，注射后35~40天处死动物的卵子数减少，血清黄体生成素和卵泡刺激素水平降低(血清FSH含量降低)。血清PRL浓度只有在发情当天被处死的动物中才能被证明是升高的。从这些结果可以得出结论，给青春期前的大鼠服用THC--即使是非常低的剂量--也会导致生殖功能的长期不可逆转的改变。强调了打击药物滥用的重要性。
The effect of the main psychoactive component of marihuana, delta-9-tetrahydrocannabinol (THC) was investigated on the onset of puberty and on the reproductive function in female rats up to the seventy-fifth to eightieth day of life. The drug was administered i.p. at a dose of 1 microgram/kg/day between the twenty-second postnatal day and the day of vaginal opening (V.O.). The administration of THC caused a 2-day delay in V. O., and the number of ova on the day of first estrus was significantly lower in treated rats than in controls. No differences were observed in serum gonadotropin and prolactin (PRL) levels on the day of V. O. After puberty, alterations occurred in the neuroendocrine functions of animals receiving THC that persisted until adulthood: estrous cycles were irregular, the number of ova in animals killed 35-40 days after V. O. was reduced, and serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels were decreased (diminution of serum FSH content was less expressed). An increase in serum PRL concentration could be demonstrated only in animals killed on the day of estrus. From these results, it might be concluded that THC administered to prepubertal rats--even in a very low dose--causes long-term irreversible alterations in reproductive functions. The importance of the fight against drug abuse is emphasized.
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Naloxone 阻断 Delta 9-四氢大麻酚对大鼠血清黄体生成素和催乳素的影响。
DOI：
--
发表时间：
1983
期刊：
Substance and alcohol actions/misuse
影响因子：
--
作者：
Kumar,MS;Simpkins,JW
通讯作者：
Simpkins,JW
对青春期有意识、自由活动的雌性大鼠血清黄体生成素分泌谱的详细分析。
影响因子：
4.8
作者：
Andrews,WW;Ojeda,SR
通讯作者：
Ojeda,SR
DOI：
--
发表时间：
1986-09
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
E. Field;L. Tyrey
通讯作者：
E. Field;L. Tyrey
体外模拟青春期前脉动黄体生成激素释放的变化可增强未成熟大鼠卵巢的孕酮和 17 β-雌二醇分泌。
影响因子：
4.8
作者：
Urbanski,HF;Ojeda,SR
通讯作者：
Ojeda,SR
雌性亚灵长类动物大麻素作用的内分泌方面：寻找作用位点。
DOI：
--
发表时间：
1984
期刊：
NIDA research monograph
影响因子：
--
作者：
Tyrey,L
通讯作者：
Tyrey,L