Effect of the artificial sweetener, sucralose, on small intestinal glucose absorption in healthy human subjects
Effect of the artificial sweetener, sucralose, on small intestinal glucose absorption in healthy human subjects
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DOI：
10.1017/s0007114510001327
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发表时间：
2010-09-01
影响因子：
3.6
通讯作者：
Rayner, Christopher K.
中科院分区：
文献类型：
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作者：
Ma, Jing;Chang, Jessica;Rayner, Christopher K.
据报道，人工甜味剂三氯蔗糖通过增强转运蛋白GLUT 2的顶端可用性来刺激啮齿动物的葡萄糖吸收。我们评估了健康受试者近端小肠暴露于三氯蔗糖是否会影响葡萄糖吸收和/或对十二指肠内（ID）葡萄糖输注的血糖反应。以单盲、随机化顺序在两个不同的场合对10例健康受试者进行了研究。每例受试者接受三氯蔗糖（4 mM，溶于0.9%生理盐水）或对照品（0.9%生理盐水）ID输注，输注速度为4 ml/min，持续150 min（T = 230 - 120 min）。30 min后（T = 0），将葡萄糖（25%）及其非代谢类似物3-O-甲基葡萄糖（3-OMG; 2.5%）经尿道内共输注（T = 0-120 min; 4.2 kJ/min（1 kcal/min））。定期采集血样。ID葡萄糖/3-OMG输注后血糖、血浆胰高血糖素样肽-1（GLP-1）和血清3-OMG浓度升高（P
It has been reported that the artificial sweetener, sucralose, stimulates glucose absorption in rodents by enhancing apical availability of the transporter GLUT2. We evaluated whether exposure of the proximal small intestine to sucralose affects glucose absorption and/or the glycaemic response to an intraduodenal (ID) glucose infusion in healthy human subjects. Ten healthy subjects were studied on two separate occasions in a single-blind, randomised order. Each subject received an ID infusion of sucralose (4mM in 0.9% saline) or control (0.9% saline) at 4 ml/min for 150 min (T = 230 to 120 min). After 30 min (T = 0), glucose (25%) and its non-metabolised analogue, 3-O-methylglucose (3-OMG; 2.5%), were co-infused intraduodenally (T = 0-120 min; 4.2 kJ/min (1 kcal/min)). Blood was sampled at frequent intervals. Blood glucose, plasma glucagon-like peptide-1 (GLP-1) and serum 3-OMG concentrations increased during ID glucose/3-OMG infusion (P