The IPD-IMGT/HLA Database.
The IPD-IMGT/HLA Database.
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DOI：
10.1093/nar/gkac1011
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发表时间：
2023-01-06
影响因子：
14.9
通讯作者：
Marsh, Steven G. E.
中科院分区：
文献类型：
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作者：
Barker, Dominic J.;Maccari, Giuseppe;Georgiou, Xenia;Cooper, Michael A.;Flicek, Paul;Robinson, James;Marsh, Steven G. E.
自IPD-IMGT/HLA数据库http：//www.ebi.ac.uk/ipd/imgt/hla/首次发布以来已有24年，该数据库为HLA社区提供了高度策划的HLA序列的可搜索存储库。该数据库现在包含超过35000个由世界卫生组织HLA系统因子命名委员会命名的人类主要组织相容性复合体（MHC）等位基因。这种复合体包含人类基因组中最多形的基因，现在被认为是高度多态的。IPD-IMGT/HLA数据库为这些信息提供了一个稳定且用户友好的存储库。近年来，下一代测序技术的采用推动了等位基因数量和提交序列长度的增加。随着数据库规模的增长，访问和呈现这些数据的传统方法受到了挑战，作为回应，我们开发了一套工具，为我们传统的基于Web的用户提供增强的用户体验，同时为我们的生物信息学用户群创建新的程序访问。这套工具由IPD-API（一种应用程序编程接口（API））提供支持，可提供对数据库的可扩展和灵活的访问。IPD-API为我们的未来发展提供了一个稳定的平台，使我们能够满足HLA领域未来的挑战和社区的需求。
It is 24 years since the IPD-IMGT/HLA Database, http://www.ebi.ac.uk/ipd/imgt/hla/, was first released, providing the HLA community with a searchable repository of highly curated HLA sequences. The database now contains over 35 000 alleles of the human Major Histocompatibility Complex (MHC) named by the WHO Nomenclature Committee for Factors of the HLA System. This complex contains the most polymorphic genes in the human genome and is now considered hyperpolymorphic. The IPD-IMGT/HLA Database provides a stable and user-friendly repository for this information. Uptake of Next Generation Sequencing technology in recent years has driven an increase in the number of alleles and the length of sequences submitted. As the size of the database has grown the traditional methods of accessing and presenting this data have been challenged, in response, we have developed a suite of tools providing an enhanced user experience to our traditional web-based users while creating new programmatic access for our bioinformatics user base. This suite of tools is powered by the IPD-API, an Application Programming Interface (API), providing scalable and flexible access to the database. The IPD-API provides a stable platform for our future development allowing us to meet the future challenges of the HLA field and needs of the community.
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影响因子：
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作者：
ALBERT, E
通讯作者：
ALBERT, E
影响因子：
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作者：
BODMER, JG;MARSH, SGE;TERASAKI, PI
通讯作者：
TERASAKI, PI
影响因子：
20.3
作者：
Crocchiolo, Roberto;Zino, Elisabetta;Benedetti, F.
通讯作者：
Benedetti, F.
影响因子：
--
作者：
Marsh SG;Albert ED;Bodmer WF;Bontrop RE;Dupont B;Erlich HA;Fernández-Viña M;Geraghty DE;Holdsworth R;Hurley CK;Lau M;Lee KW;Mach B;Maiers M;Mayr WR;Müller CR;Parham P;Petersdorf EW;Sasazuki T;Strominger JL;Svejgaard A;Terasaki PI;Tiercy JM;Trowsdale J
通讯作者：
Trowsdale J
影响因子：
14.9
作者：
Amid, Clara;Birney, Ewan;Cochrane, Guy
通讯作者：
Cochrane, Guy