Effects of different monochromatic lights on refractive development and eye growth in guinea pigs
Effects of different monochromatic lights on refractive development and eye growth in guinea pigs
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DOI：
10.1016/j.exer.2011.03.003
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发表时间：
2011-06-01
影响因子：
3.4
通讯作者：
Chu, Ren-Yuan
中科院分区：
文献类型：
--
作者：
Liu, Rui;Qian, Yi-Feng;Chu, Ren-Yuan
我们研究了不同的单色光具有相似的亮度或相同的光量子数是否产生可预测的变化，在豚鼠眼发育早期的屈光状态和眼睛的生长。在实验I中，三组豚鼠（两周龄，每组n = 18）在430 nm（短波长光，SL）、530 nm（中波长光，ML）和宽带光（BL）的LED照明下饲养12周。设置照明条件以提供相等的亮度水平。所有动物每2周进行一次屈光和生物测定。实验二设等量子数光照条件，另设三组豚鼠饲养20周。在实验I中，与BL组相比，ML组的屈光度较低（P < 0.001），玻璃体延伸较快（P <0.001），而SL组的屈光度较高，玻璃体延伸较慢（P < 0.001）。SL组和ML组之间的平均屈光差异最大达到约4.5 D。在前12周期间，实验II中的屈光变化和眼睛生长与实验I非常相似，但SL和ML组之间的屈光差异在治疗20周后达到6.05 D，这大于豚鼠眼睛中的纵向色差（约1.5 D）。结果表明，豚鼠的眼睛在对窄带光的反应中过度补偿，这导致了夸张和不准确的屈光增长。(C)2011爱思唯尔有限公司保留所有权利。
We investigated whether different monochromatic lights with similar luminance or identical light quantum number produce predictable changes in refractive state and eye growth in early eye development in guinea pigs. In experiment I, three groups of guinea pigs (two weeks of age, n = 18 in each group) were reared for 12 weeks under LED lighting of 430 nm (short-wavelength light, SL), 530 nm (middle-wavelength light, ML), and broad-band light (BL). The lighting conditions were set to provide equal levels of luminance. All animals underwent refraction and biometric measurements every 2 weeks. In experiment II, the lighting conditions were set at equal quantum number and another three groups of guinea pigs were raised and tested for 20 weeks. In experiment I, compared to the BL group, refraction of the ML group was less hyperopic (P < 0.001) with a faster vitreous extension (P < 0.001), while the SL group was more hyperopic with a slower vitreous elongation (P < 0.001). The mean difference in refraction between the SL and ML groups reached about 4.5 D at maximum. The refractive changes and eye growth in experiment II were very similar to experiment I during the first 12 weeks, but the difference in refraction between the SL and ML groups reached 6.05 D after 20 weeks of treatment, which was greater than the longitudinal chromatic aberration (approximately 1.5 D) in the guinea pigs eyes. The results suggest that the guinea pigs' eyes overcompensated in response to narrow-band light, which resulted in an exaggerated and inaccurate refractive growth. (C) 2011 Elsevier Ltd. All rights reserved.