Rewarding effects of ethanol and cocaine in μ opioid receptor-deficient mice
Rewarding effects of ethanol and cocaine in μ opioid receptor-deficient mice
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DOI：
10.1007/s00210-002-0533-2
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发表时间：
2002-04-01
影响因子：
3.6
通讯作者：
Höllt, V
中科院分区：
文献类型：
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作者：
Becker, A;Grecksch, G;Höllt, V
为了探讨Mu阿片受体在精神药物增强效应中的作用，我们测试了Mu阿片受体缺陷小鼠及其野生型配对小鼠的自愿性酒精摄入以及乙醇和可卡因诱导的条件性位置偏爱。此外，还检测了多巴胺D1和D2受体的结合。研究发现，在缺乏乙醇的小鼠中，乙醇的摄入量显著减少。用5.0 mg/kg的可卡因诱导野生型动物的条件性位置偏爱，该剂量的可卡因在基因敲除中无效。本组大鼠在注射可卡因10.0 mg/kg后出现条件性位置偏爱。可卡因在两组小鼠的运动活动中都有类似的增加。多巴胺D_1受体结合无差异，而多巴胺D_2受体结合在缺陷动物海马区显著降低。这表明阿片系统和多巴胺能系统之间的相互作用可能解释了对药物反应的差异。
To investigate the role of mu opioid receptors in the reinforcing effects of psychotropic drugs, the voluntary ethanol intake and ethanol- and cocaine-induced conditioned place preference in mu opioid receptor-deficient mice and their wild-type counterpartners was tested. Moreover, dopamine D1 and D2 receptor binding was measured. It was found that ethanol intake was significantly lower in deficient mice. Conditioned place preference in wild-type animals was induced with 5.0 mg/kg cocaine and this dose was ineffective in the knockouts. In this group conditioned place preference occurred after injection of 10.0 mg/kg cocaine. Cocaine induced a similar increase in locomotor activity in both groups of mice. There was no difference in dopamine D1 receptor binding, whereas dopamine D2 receptor binding was significantly lower in the hippocampus of deficient animals. This suggests that interaction between opioid systems and dopaminergic systems may account for the differences in responding to the drugs.