BF2-Azadipyrromethenes: Probing the Excited-State Dynamics of a NIR Fluorophore and Photodynamic Therapy Agent
BF2-Azadipyrromethenes: Probing the Excited-State Dynamics of a NIR Fluorophore and Photodynamic Therapy Agent
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DOI：
10.1021/jp2077775
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发表时间：
2011-12-08
影响因子：
2.9
通讯作者：
McClenaghan, Nathan D.
中科院分区：
文献类型：
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作者：
Batat, Pinar;Cantuel, Martine;McClenaghan, Nathan D.
bf2 -偶氮吡咯甲烷染料是一类很有前途的近红外发射体（非卤化）和光敏剂（卤化）。光谱研究的基准例子的每一种类型，包括吸收（一个和两个光子），时间分辨瞬态吸收（ps-ms）和荧光，报告。快速光动力学表明，强烈的纳秒NW荧光在溴化模拟物中淬灭，产生持久的（21 μ s）瞬态吸收特征。这些变化的动力学被确定并归因于三重态的有效居群（72%），它可以有效地敏化单线态氧的形成（约74%），直接观察到(1)δ (g)发光。光稳定性测量显示了极高的稳定性，特别是对于非卤化变体，其稳定性至少是10(3)倍（Phi（光敏度））。= < 10(-8))比一些代表性的BODIPY和荧光素染料。
BF2-Azadipyrromethene dyes are a promising class of NIR emitter (nonhalogenated) and photosensitizer (halogenated). Spectroscopic studies on a benchmark example of each type, including absorption (one and two photon), time-resolved transient absorption (ps-ms) and fluorescence, are reported. Fast photodynamics reveal that intense nanosecond NW fluorescence is quenched in a brominated analog, giving rise to a persistent (21 mu s) transient absorption signature. Kinetics for these changes are determined and ascribed to the efficient population of a triplet state (72%), which can efficiently sensitize singlet oxygen formation (ca. 74%), directly observed by (1)Delta(g) luminescence. Photostability measurements reveal extremelz high stability, notably for the nonhalogenated variant, which is at least 10(3)-times more stable (Phi(photodeg). = < 10(-8)) than some representative BODIPY and fluorescein dyes.