Retinoids inhibit prolactin-induced development of the mammary gland in vitro.
Retinoids inhibit prolactin-induced development of the mammary gland in vitro.
复制标题
类视黄醇在体外抑制催乳素诱导的乳腺发育。
DOI：
10.1093/carcin/4.1.23
复制
发表时间：
1983
期刊：
影响因子：
4.7
通讯作者：
Moon,RC
中科院分区：
文献类型：
--
作者：
Mehta,RG;Cerny,WL;Moon,RC
Mouse mammary gland organ culture technique was utilized to determine the effects of retinoids on the prolacnn-induced structural differentiation of the mammary gland. Thoracic glands from BALB/c mice pretreated with steroids differentiate in 6 days into alveolar structures in presence of insulin and prolactin. All-trans-retinoic acid and N-(4-hydroxy-phenyl)retinamide inhibit prolactin-induced structural changes in the glands. Retinyl acetate, which is effective against mammary carcinogenesis in the rat, but is ineffective against mouse mammary carcinogenesis, failed to inhibit such proliferation. These results were correlated with inhibition of [3H]thymidine incorporation into DNA in a dose related manner by retinoids effective in inhibiting mammary development.
