The type IV phosphodiesterase inhibitors, Ro 20-1724 and rolipram, block the initiation of cocaine self-administration
The type IV phosphodiesterase inhibitors, Ro 20-1724 and rolipram, block the initiation of cocaine self-administration
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DOI：
10.1016/s0091-3057(98)00154-3
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发表时间：
1999-01-01
影响因子：
3.6
通讯作者：
Kornetsky, C
中科院分区：
文献类型：
--
作者：
Knapp, CM;Foye, MM;Kornetsky, C
选择性激活环AMP （cAMP）信号转导通路将抑制可卡因自我给药的开始的假设在本研究中进行了检验。为了验证这一假设，我们测定了camp特异性（IV型）磷酸二酯酶抑制剂罗利普兰和Ro 20-1724对可卡因自我给药的影响。研究了ro20 -1724处理对食性反应的影响。可卡因和食物都是按照固定的比例运送的。用罗利普兰或ro20 -1724治疗可显著增加第一次可卡因输注的潜伏期，减少每次治疗的输注次数。ro20 -1724对食物的反应也有类似的效果。药物引起的延迟后的反应往往处于控制水平。这些结果表明，camp特异性磷酸二酯酶抑制剂可能抑制可卡因或食物的操作性反应的开始。然而，这些行动在多大程度上涉及对中央动机系统的具体影响，而不是对其他机制的影响，仍有待确定。(C) 1998爱思唯尔科学有限公司
The hypothesis that the selective activation of cyclic AMP (cAMP) signal transduction pathways will suppress the initiation of cocaine self-administration was examined in this investigation. To test this hypothesis, the effects of the administration of the cAMP-specific (type IV) phosphodiesterase inhibitors, rolipram and Ro 20-1724, on cocaine self-administration were determined. The effects of Ro 20-1724 treatment on operant responding for food also were examined. Both cocaine and food were delivered following a fixed-ratio 5 schedule. A significant increase in the latency for the delivery of the first cocaine infusion and a reduction in the number of infusions obtained per session were produced by treatment with either rolipram or Ro 20-1724. Similar effects on responding for food were seen with Ro 20-1724 administration. Responding after drug-induced delays tended to be at control levels. These results suggest that cAMP-specific phosphodiesterase inhibitors may inhibit the initiation of operant responding for either cocaine or food. However, the extent to which these actions involve specific effects on central motivational systems as opposed to other mechanisms remains to be determined. (C) 1998 Elsevier Science Inc.