Effects of acute microwave irradiation on phenobarbital sleep and disposition to brain in mice
Effects of acute microwave irradiation on phenobarbital sleep and disposition to brain in mice
复制标题
急性微波照射对小鼠苯巴比妥睡眠及脑处置的影响
DOI：
10.1080/15287398309530340
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
T. Ishii
中科院分区：
文献类型：
--
作者：
E. B. Benson;D. Lange;J. Fujimoto;T. Ishii
在近场暴露于功率密度为10 MW /cm2的2.45 GHz微波（MW）假辐射10分钟后，雄性瑞士-考克斯小鼠被注射苯巴比妥钠（150 mg/kg, iv），并记录了苯巴比妥钠诱导睡眠的开始和持续时间。在辐照后1 ~ 45分钟给予PB时，MW‐预处理小鼠的PB睡眠发生率比假手术小鼠低；然而，24小时后未见效果。PB诱导的睡眠持续时间增加；然而，MW预处理不影响六巴比妥或戊巴比妥诱导睡眠的持续时间。在铅诱导睡眠开始时，MW -辐照组和对照组的脑内铅浓度相同，尽管两组之间的睡眠开始时间相差两倍。但是，在注射PB后5分钟测量时，经MW‐预处理的小鼠脑内PB浓度更高，这表明一种性格机制解释了所观察到的MW对PB‐诱导睡眠的影响。老鼠加热1…
Following a 10‐min near‐field exposure to sham radiation of 2.45 GHz microwave (MW) radiation at a power density of 10 mW/cm2, male Swiss‐Cox mice were injected with sodium phenobarbital (PB) (150 mg/kg, iv) and the onset and duration of PB‐induced sleep were recorded. MW‐pretreated mice exhibited a decreased PB sleep onset relative to sham when PB was administered 1 to 45 min following irradiation; however, no effect was seen by 24 h. The duration of PB‐induced sleep was increased; however MW pretreatment did not affect the duration of hexobarbital‐ or pento‐barbital‐induced sleep. At the time of onset of PB‐induced sleep, PB concentrations in brain of MW‐irradiated and control groups were the same despite a twofold difference in the time to sleep onset between these groups. But, when measured 5 min following PB injection, the PB concentrations in brain were higher in MW‐pretreated mice, suggesting that a dispositional mechanism accounted for the observed MW effects on PB‐induced sleep. Mice heated for 1...