Chloramphenicol, an inhibitor of mitochondrial protein synthesis, inhibits myoblast fusion and myotube differentiation.
Chloramphenicol, an inhibitor of mitochondrial protein synthesis, inhibits myoblast fusion and myotube differentiation.
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氯霉素是一种线粒体蛋白质合成抑制剂，可抑制成肌细胞融合和肌管分化。
DOI：
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发表时间：
1993
影响因子：
1.5
通讯作者：
K. Reiss
中科院分区：
文献类型：
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作者：
W. Korohoda;Z. Pietrzkowski;K. Reiss
氯霉素 (100 微克/毫升) 是一种线粒体蛋白质合成抑制剂，在补充血清和无血清培养条件下均可抑制从鸡胚胸肌分离的成肌细胞的融合。这种对肌管形成的抑制似乎仅在确定的培养基中是可逆的。当在氯霉素存在的情况下添加胰蛋白胨磷酸肉汤和核苷时，能够恢复细胞增殖的能力，但不能恢复融合和分化的能力。
Chloramphenicol (100 micrograms/ml), an inhibitor of mitochondrial protein synthesis, inhibits the fusion of myoblasts isolated from chick embryo pectoral muscle in both, serum supplemented and serum-free culture conditions. This inhibition of myotube formation appeared reversible only in the defined media. Tryptose phosphate broth and nucleosides, when added in the presence of chloramphenicol, were able to restore the cell capacity to proliferate but not to fuse and differentiate.