Artificial vision
Artificial vision
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DOI：
10.1038/eye.1998.151
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发表时间：
1998-06-01
期刊：
影响因子：
3.9
通讯作者：
de Juan, E
中科院分区：
文献类型：
--
作者：
Humayun, MS;de Juan, E
视网膜色素变性（RP）和年龄相关性黄斑变性（AMD）等外部视网膜变性由于感光细胞变性而导致失明。为了测试剩余的视网膜神经元的受控电刺激是否可以提供形式视觉，我们用微电极电刺激这些患者中的14个（12个RP和2个AMD）的巩膜/眼壁的视网膜内表面。该程序在局部麻醉下在手术室中进行，并且通过安装在手术显微镜上的摄像机记录所有反应。视网膜内表面的电刺激引起了所有受试者对光点（光幻视）的视觉感知。14例患者中有13例视网膜定位正确。在对无光感的受试者进行的分辨力测试中，患者可以分辨中心距为1.75度的光幻视（即，视力与活动性相容; Snellen视力为4/200）。
Outer retinal degenerations such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD) lead to blindness because of photoreceptor degeneration. To test whether controlled electrical stimulation of the remaining retinal neurons could provide form vision, we electrically stimulated the inner retinal surface with micro-electrodes inserted through the sclera/eye wall of 14 of these patients (12 RP and 2 AMD). This procedure was performed in the operating room under local anaesthesia and all responses were recorded via a video camera mounted on the surgical microscope. Electrical stimulation of the inner retinal surface elicited visual perception of a spot of light (phosphene) in all subjects. This perception was retinotopically correct in 13 of 14 patients. In a resolution test in a subject with no light perception, the patient could resolve phosphenes at 1.75 degrees centre-to-centre distance (i.e. visual acuity compatible with mobility; Snellen visual acuity of 4/200).