Macrophage cell death upon intracellular bacterial infection.
Macrophage cell death upon intracellular bacterial infection.
复制标题
DOI：
10.14800/macrophage.779
复制
发表时间：
2015-04-26
期刊：
影响因子：
--
通讯作者：
Ren Y
中科院分区：
文献类型：
--
作者：
Lai XH;Xu Y;Chen XM;Ren Y
巨噬细胞与病原体的相互作用是一个复杂的过程，这场战争的结果对双方来说都是生存或死亡。本文将讨论巨噬细胞与一些兼性细胞内细菌病原体相互作用结果的复杂性和意义，如弗朗西斯菌、沙门氏菌、志贺氏菌和耶尔森菌。在细菌感染后，巨噬细胞可以多种方式死亡，如凋亡、自噬细胞死亡、坏死、坏死坏死、肿瘤、热坏死、焦亡等，这是本文综述的重点。
Macrophage-pathogen interaction is a complex process and the outcome of this tag-of-war for both sides is to live or die. Without attempting to be comprehensive, this review will discuss the complexity and significance of the interaction outcomes between macrophages and some facultative intracellular bacterial pathogens as exemplified by Francisella, Salmonella, Shigella and Yersinia. Upon bacterial infection, macrophages can die by a variety of ways, such as apoptosis, autophagic cell death, necrosis, necroptosis, oncosis, pyronecrosis, pyroptosis etc, which is the focus of this review.