The effects of Morinda citrifolia L. (noni) on the immune system:: Its molecular mechanisms of action
The effects of Morinda citrifolia L. (noni) on the immune system:: Its molecular mechanisms of action
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DOI：
10.1016/j.jep.2007.10.023
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发表时间：
2008-02-12
影响因子：
5.4
通讯作者：
White, Leland
中科院分区：
文献类型：
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作者：
Palu, Afa K.;Kim, Anne Hirazumi;White, Leland
本研究旨在探讨桑葚在体外和体内对小鼠免疫调节作用的机制。塔希提诺丽果汁（TNJ）和诺丽果汁浓缩液（NFJC） （1,5 mg/mL）在体外对大麻素2 （CB2）有明显的激活作用，但对大麻素1 （cb1）受体的抑制作用呈浓度依赖性。在体内，随意口服TNJ 16天降低了IL-4的产生，但增加了ifn - γ的产生。这些结果表明，nom通过激活CB2受体和抑制IL-4调节免疫系统，但增加ifn - γ细胞因子的产生。在免疫反应不足的情况下，它也可能发挥有益的免疫调节作用。2007爱思唯尔爱尔兰有限公司版权所有。
The aim of this study was to investigate the mechanisms involved in the immunomodulatory effects of Morinda citrifolia L. (nom) in vitro and in vivo in mice. In vitro, Tahitian Noni (R) Juice (TNJ) and Noni fruitjuice concentrates (NFJC) (1, 5 mg/mL) potently activate cannabinoid 2 (CB2), but inhibit cannabinoid I (CB 1) receptors in a concentration-dependant manner. In vivo, oral administration of TNJ ad libitum for 16 days decreased the production of IL-4, but increased the production of IFN-gamma. These results suggest that nom modulates the immune system via activating of the CB2 receptors, and suppressing of the IL-4, but increasing the production of IFN-gamma cytokines. It may also exert beneficial immunomodulation effects in conditions involving inadequate immune responses. (c) 2007 Elsevier Ireland Ltd. All rights reserved.