The anatomical problem posed by brain complexity and size: a potential solution.
The anatomical problem posed by brain complexity and size: a potential solution.
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大脑复杂性和大小提出的解剖问题：潜在的解决方案。
DOI：
10.3389/fnana.2015.00104
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发表时间：
2015
影响因子：
2.9
通讯作者：
DeFelipe J
中科院分区：
文献类型：
--
作者：
DeFelipe J
多年来，神经解剖学领域已经有了很大的发展，但解开大脑非凡的结构和功能复杂性似乎是一个无法实现的目标，部分原因是它只能获得一个不精确的大脑连接矩阵。这里讨论了为什么达到这样一个目标似乎几乎不可能的原因，以及我们如何通过建立新的方法来研究大脑和促进跨学科合作来克服这个解剖学问题的建议。生成一个逼真的计算模型似乎是解决方案，而不是试图完全重建整个大脑或特定的大脑区域。
Over the years the field of neuroanatomy has evolved considerably but unraveling the extraordinary structural and functional complexity of the brain seems to be an unattainable goal, partly due to the fact that it is only possible to obtain an imprecise connection matrix of the brain. The reasons why reaching such a goal appears almost impossible to date is discussed here, together with suggestions of how we could overcome this anatomical problem by establishing new methodologies to study the brain and by promoting interdisciplinary collaboration. Generating a realistic computational model seems to be the solution rather than attempting to fully reconstruct the whole brain or a particular brain region.