Histopathological diagnostic value of the IgG4+/IgG+ ratio of plasmacytic infiltration for IgG4-related diseases: a PRISMA-compliant systematic review and meta-analysis.
Histopathological diagnostic value of the IgG4+/IgG+ ratio of plasmacytic infiltration for IgG4-related diseases: a PRISMA-compliant systematic review and meta-analysis.
复制标题
浆细胞浸润的 IgG4( )/IgG( ) 比率对 IgG4 相关疾病的组织病理学诊断价值 符合 PRISMA 的系统评价和荟萃分析
DOI：
10.1097/md.0000000000000579
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发表时间：
2015-03
期刊：
影响因子：
1.6
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Deng C;Li W;Chen S;Zhang W;Li J;Hu C;Wen X;Zhang F;Li Y
本文旨在通过荟萃分析评价浆细胞浸润免疫球蛋白G (IgG)4+/IgG+比值对igg4相关疾病的诊断价值。四个数据库——embase、ISI Web of Knowledge、PubMed和Cochrane图书馆——被系统地检索。这项研究包括了来自几个研究的大约200名参与者。采用STATA 11.2软件（STATA Corporation, College Station， TX）和Meta-DiSc 1.4（临床生物统计学单元，Ramon y Cajal医院，Madrid, Spain）进行meta分析。荟萃分析纳入了9项研究。合并诊断优势比为18.94[95%可信区间（CI）， 2.89-124.30]。敏感性为58.80% (95% CI, 50.90 ~ 66.30)，特异性为90.20% （95% CI, 81.20 ~ 95.80）。阳性和阴性似然比分别为3.12 （95% CI, 1.07-9.16）和0.26 （95% CI, 0.09-0.70）。受者工作特征曲线下面积为0.88。综上所述，浆细胞浸润IgG4+/IgG+比值在诊断IgG相关疾病中具有中等有效性。
This article aims to perform a meta-analysis to evaluate the diagnostic value of the immunoglobulin G (IgG)4+/IgG+ ratio of plasmacytic infiltration for IgG4-related diseases. Four databases—EMBASE, ISI Web of Knowledge, PubMed, and the Cochrane Library—were systematically searched. Approximately 200 participants from several studies were included in this research. STATA 11.2 software (Stata Corporation, College Station, TX) and Meta-DiSc 1.4 (Unit of Clinical Biostatistics, Ramon y Cajal Hospital, Madrid, Spain) were used to perform the meta-analysis. Nine studies were included in the meta-analysis. The pooled diagnostic odds ratio was 18.94 [95% confidence interval (CI), 2.89–124.30]. The sensitivity was 58.80% (95% CI, 50.90–66.30) and the specificity was 90.20% (95% CI, 81.20–95.80). The positive and negative likelihood ratios were 3.12 (95% CI, 1.07–9.16) and 0.26 (95% CI, 0.09–0.70), respectively. The area under the curve of the summary receiver-operating characteristic was 0.88. To conclude, the IgG4+/IgG+ ratio of plasmacytic infiltration is modestly effective in diagnosing IgG-related disease.