Carbapenem-Resistant Non-Glucose-Fermenting Gram-Negative Bacilli: the Missing Piece to the Puzzle
Carbapenem-Resistant Non-Glucose-Fermenting Gram-Negative Bacilli: the Missing Piece to the Puzzle
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DOI：
10.1128/jcm.03264-15
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发表时间：
2016-07-01
影响因子：
9.4
通讯作者：
Simner, Patricia J.
中科院分区：
文献类型：
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作者：
Gniadek, Thomas J.;Carroll, Karen C.;Simner, Patricia J.
非葡萄糖发酵革兰氏阴性杆菌铜绿假单胞菌和鲍曼不动杆菌对碳青霉烯类抗生素的耐药性日益增加。鉴于其固有的抗生素耐药性，这可能导致极难治疗的感染。此外，耐药基因转移可以发生在革兰氏阴性菌种之间，无论它们发酵葡萄糖的能力如何。因此，这些微生物获得碳青霉烯酶基因通常会增加碳青霉烯酶传播的风险。最终，感染控制从业者和临床微生物学家需要共同努力，确定其机构中碳青霉烯类耐药非葡萄糖发酵革兰氏阴性杆菌（CR-NF）所带来的风险，以及应考虑采用哪些方法来监测和检测CR-NF。
The non-glucose-fermenting Gram-negative bacilli Pseudomonas aeruginosa and Acinetobacter baumannii are increasingly acquiring carbapenem resistance. Given their intrinsic antibiotic resistance, this can cause extremely difficult-to-treat infections. Additionally, resistance gene transfer can occur between Gram-negative species, regardless of their ability to ferment glucose. Thus, the acquisition of carbapenemase genes by these organisms increases the risk of carbapenemase spread in general. Ultimately, infection control practitioners and clinical microbiologists need to work together to determine the risk carried by carbapenem-resistant non-glucose-fermenting Gram-negative bacilli (CR-NF) in their institution and what methods should be considered for surveillance and detection of CR-NF.