Bronchiectasis and Nontuberculous Mycobacterial Disease
Bronchiectasis and Nontuberculous Mycobacterial Disease
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DOI：
10.1016/j.ccm.2012.02.002
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发表时间：
2012-06-01
影响因子：
5.7
通讯作者：
Aksamit, Timothy R.
中科院分区：
文献类型：
--
作者：
Griffith, David E.;Aksamit, Timothy R.
在过去的30年里，越来越清楚的是，非结核分枝杆菌（NTM）肺部感染和支气管扩张症是密切相关的疾病。尽管缺乏无可争议的证据，但越来越多的人一致认为，以结节和支气管扩张为特征的NTM肺病（结节性/支气管扩张性NTM肺病）可能是预先存在的支气管扩张的结果，支气管扩张易导致NTM感染和疾病。为了有效地使用已发表的诊断指南，医生必须熟悉单个NTM物种的致病潜力。基本上所有NTM患者都有支气管扩张，因此最佳的整体患者管理需要成功的NTM感染和支气管扩张的治疗策略。
Over the last 30 years it has become increasingly clear that nontuberculous mycobacterial (NTM) lung infections and bronchiectasis are closely related disorders. Although incontrovertible proof is lacking, there is a growing consensus of opinion that NTM lung disease characterized by nodules and bronchiectasis (nodular/bronchiectatic NTM lung disease) may be a consequence of preexisting bronchiectasis that predisposes to NTM infection and disease. To use published diagnostic guidelines effectively, physicians must become familiar with the disease-causing potential of individual NTM species. Essentially all NTM patients have bronchiectasis, so optimal overall patient management requires successful therapeutic strategies for both NTM infection and bronchiectasis.