Photoredox-Catalyzed Multicomponent Petasis Reaction with Alkyltrifluoroborates
Photoredox-Catalyzed Multicomponent Petasis Reaction with Alkyltrifluoroborates
复制标题
光氧化还原催化的多组分与烷基三氟硼酸盐的堆积反应
DOI：
10.1021/acs.orglett.9b01747
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发表时间：
2019-06-21
期刊：
影响因子：
5.2
通讯作者：
Molander, Gary A.
中科院分区：
文献类型：
--
作者：
Yi, Jun;Badir, Shorouk O.;Molander, Gary A.
发展了一种通过光氧化还原催化进行的氧化还原-中性烷基彼塔什反应。一系列不同的伯烷基、仲氟化硼和叔烷基三氟化硼通过单电子转移机制有效地参与了这一反应，而传统的两电子Petsis反应只支持不饱和的硼酸。该协议非常适合于使苄基和乙醛衍生的醛、苯胺和烷基三氟硼酸盐多样化，从而快速组装在制药和农用化学环境中重要的更高分子复杂性的文库。
A redox-neutral alkyl Petasis reaction has been developed that proceeds via photoredox catalysis. A diverse set of primary, secondary, and tertiary alkyltrifluoroborates participate effectively in this reaction through a single-electron transfer mechanism, in contrast to the traditional two-electron Petasis reaction, which accommodates only unsaturated boronic acids. This protocol is ideal to diversify benzyl-type and glyoxalate-derived aldehydes, anilines, and alkyltrifluoroborates toward the rapid assembly of libraries of higher molecular complexity important in pharmaceutical and agrochemical settings.