Intratracheal recombinant human deoxyribonuclease in acute life-threatening asthma refractory to conventional treatment
Intratracheal recombinant human deoxyribonuclease in acute life-threatening asthma refractory to conventional treatment
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DOI：
10.1093/oxfordjournals.bja.a013479
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发表时间：
2000-04-01
影响因子：
9.8
通讯作者：
Murdoch, IA
中科院分区：
文献类型：
--
作者：
Patel, A;Harrison, E;Murdoch, IA
重组人脱氧核糖核酸酶 (rhDNase) 是一种粘液溶解剂，用于缓解囊性纤维化患者的外周气道阻塞。我们报道了一名患有急性危及生命的哮喘的 3 岁男孩，经过 48 小时的积极治疗失败，在气管内注射 rhDNase 后，病情得到了显着的持续改善。
Recombinant human deoxyribonuclease (rhDNase) is a mucolytic agent used to relieve peripheral airway obstruction in patients with cystic fibrosis. We report dramatic sustained improvement following the intratracheal administration of rhDNase to a 3-yr-old boy with acute life-threatening asthma in whom 48 h of aggressive therapy had failed.