Global burden of human food-borne trematodiasis: a systematic review and meta-analysis
Global burden of human food-borne trematodiasis: a systematic review and meta-analysis
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DOI：
10.1016/s1473-3099(11)70294-8
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发表时间：
2012-03-01
影响因子：
56.3
通讯作者：
Utzinger, Juerg
中科院分区：
文献类型：
--
作者：
Fuerst, Thomas;Keiser, Jennifer;Utzinger, Juerg
背景食源性吸虫病是由肝、肺、肠道寄生虫感染引起的一组被忽视的热带疾病。作为《全球疾病、伤害和危险因素负担研究》(GBD 2010研究)和世界卫生组织倡议的一部分，我们评估了2005年全球食源性吸虫病的负担，以伤残调整生命年(DALY)表示。方法我们系统地检索电子数据库，在1980年1月1日至2008年12月31日期间无语言限制的人类食源性吸虫病报告。我们使用了广泛的搜索策略，结合了搜索词以及寄生虫和疾病的名称。然后根据标题、摘要，最后是全文，对最初的搜索结果进行筛选。提取了有关食源性吸虫病的人类患病率、发病率和死亡率的相关定量和定性数据。根据现有的病理和临床表现信息，我们建立了简化的疾病模型，对特定后遗症的比例和优势比进行了荟萃分析，并估计了人类食源性吸虫病的全球负担。结果，我们筛选了33921篇文章，确定了181项包含定量信息的合格研究纳入荟萃分析。2005年，约有5620万人感染了食源性吸虫：790万人有严重后遗症，7158人死亡，其中大多数死于胆管癌和脑部感染。综上所述，我们估计全球食源性吸虫病的负担为665 352个DALY(较低估计为479 496个DALY；较高估计为859 051个DALY)。此外，在关键的流行病学疾病参数和估计全球寄生虫病负担的方法学特征方面的知识差距被突出，这些特征具有高度集中的空间发生和稀缺和零星的信息。
Background Food-borne trematodiases are a group of neglected tropical diseases caused by liver, lung, and intestinal parasitic fluke infections. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD 2010 study) and a WHO initiative, we assessed the global burden of human food-borne trematodiasis, as expressed in disability-adjusted life years (DALYs) for the year 2005.Methods We systematically searched electronic databases for reports about human food-borne trematodiasis without language restriction, between Jan 1, 1980, and Dec 31, 2008. We used a broad search strategy with a combination of search terms and parasite and disease names. The initial search results were then screened on the basis of title, abstract, and, finally, full text. Relevant quantitative and qualitative data on human prevalence, morbidity, and mortality of food-borne trematodiasis were extracted. On the basis of available information on pathological and clinical appearance, we developed simplified disease models and did meta-analyses on the proportions and odds ratios of specified sequelae and estimated the global burden of human food-borne trematodiasis.Findings We screened 33 921 articles and identified 181 eligible studies containing quantitative information for inclusion in the meta-analyses. About 56.2 million people were infected with food-borne trematodes in 2005: 7.9 million had severe sequelae and 7158 died, most from cholangiocarcinoma and cerebral infection. Taken together, we estimate that the global burden of food-borne trematodiasis was 665 352 DALYs (lower estimate 479 496 DALYs; upper estimate 859 051 DALYs). Furthermore, knowledge gaps in crucial epidemiological disease parameters and methodological features for estimating the global burden of parasitic diseases that are characterised by highly focal spatial occurrence and scarce and patchy information were highlighted.Interpretation Despite making conservative estimates, we found that food-borne trematodiases are an important cluster of neglected diseases.