Compensatory evolution in diploid populations
Compensatory evolution in diploid populations
复制标题
DOI：
10.1016/j.tpb.2008.07.002
复制
发表时间：
2008-09-01
影响因子：
1.4
通讯作者：
Takefu, Masasuke
中科院分区：
文献类型：
--
作者：
Ichinose, Motoshi;Iizuka, Masaru;Takefu, Masasuke
补偿性突变在单个情况下是有害的，但在适当的组合中是无害的，无论是在一个基因内的两个以上位点还是在不同的基因上。考虑到选择的显性效应和基因产物异二聚体的形成可能影响补偿进化的速率，我们研究了二倍体群体的补偿中性突变模型。我们对补偿突变固定的平均时间的理论分析表明，如果突变率不低，这些因素在减少补偿突变的固定时间方面起着重要作用。如果单突变体的有害影响是隐性的，异二聚体的补偿进化更容易发生。(C)2008年爱思唯尔公司All rights reserved.
Compensatory mutations are individually deleterious but harmless in appropriate combinations either at more than two sites within a gene or on separate genes. Considering that dominance effects of selection and heterodimer formation of gene products may affect the rate of compensatory evolution, we investigate compensatory neutral mutation models for diploid populations. Our theoretical analysis on the average time until fixation of compensatory mutations shows that these factors play an important role in reducing the fixation time of compensatory mutations if mutation rates are not low. Compensatory evolution of heterodimers is shown to occur more easily if the deleterious effects of single mutants are recessive. (C) 2008 Elsevier Inc. All rights reserved.