The CSF Levels of Neutrophil-Related Chemokines in Patients with Neuromyelitis Optica
The CSF Levels of Neutrophil-Related Chemokines in Patients with Neuromyelitis Optica
复制标题
视神经脊髓炎患者脑脊液中性粒细胞相关趋化因子水平
DOI：
10.1002/acn3.51094
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发表时间：
2020-06-09
影响因子：
5.3
通讯作者：
Peng, Yu
中科院分区：
文献类型：
--
作者：
Liu, Zhuhe;Chen, Jinyu;Peng, Yu
病理结果显示中性粒细胞在NMO的发病中起重要作用。本研究旨在探讨NMO患者脑脊液中嗜中性粒细胞相关趋化因子的水平。在95例NMO患者、15例MS患者、18例GFAP星形细胞病患者和16例对照者中测定了CXCL1、CXCL5和CXCL7。在NMO组中，CXCL1、CXCL5和CXCL7的CSF水平显著升高，但与患者的临床严重程度无关。此外，CSFCXCL1、CXCL5和CXCL7可作为鉴别NMO和MS的生物标志物，具有良好的可靠性，尤其是CXCL7。
Pathologic findings showed that neutrophils played an important role in the pathogenesis of NMO. This study aims to investigate the CSF levels of neutrophil-related chemokines in NMO. CXCL1, CXCL5, and CXCL7 were measured in 95 patients with NMO, 15 patients with MS, 18 patients with GFAP astrocytopathy, and 16 controls. The CSF level of CXCL1, CXCL5, and CXCL7 was significantly elevated in the NMO group but not correlated with the patient clinical severity. Besides, the CSF CXCL1, CXCL5, and CXCL7 could act as biomarkers to distinguish NMO from MS with good reliability, especially the CXCL7.