The maintenance of an oral epithelial barrier.
The maintenance of an oral epithelial barrier.
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DOI：
10.1016/j.lfs.2019.04.029
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发表时间：
2019-06
期刊：
影响因子：
6.1
通讯作者：
Sha-Sha Wang-Sha;Ya-Ling Tang;Xin Pang;Min Zheng;Ya-Jie Tang;Xin-hua Liang
中科院分区：
文献类型：
--
作者：
Sha-Sha Wang-Sha;Ya-Ling Tang;Xin Pang;Min Zheng;Ya-Jie Tang;Xin-hua Liang
Oral epithelial barrier consists of closely controlled structure of the stratified squamous epithelium, which is the gateway to human bodies and encounters a huge burden of microbial, airborne and dietary antigens, as well as masticatory damage. Once this barrier is destroyed, it will trigger bone loss, tissue damage and microbial dysbiosis and lead to diseases, such as periodontitis, oral mucosal diseases and oral cancer. Recently, increasing evidences showed that different factors including microorganism, saliva, proteins and immune components have been considered to play a critical role in the disruption of oral epithelial barrier. Herein, we discussed mechanisms governing the maintenance of oral epithelial barrier. Besides, the role of oral epithelial barrier failure in oral carcinogenesis will also be talked about.
