Caffeic acid attenuates the decrease of cortical BDNF transcript IV mRNA induced by swim stress in wild-type but not in 5-lipoxygenase-deficient mice
Caffeic acid attenuates the decrease of cortical BDNF transcript IV mRNA induced by swim stress in wild-type but not in 5-lipoxygenase-deficient mice
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DOI：
10.1007/s00702-008-0034-7
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发表时间：
2008-06-01
影响因子：
3.3
通讯作者：
Manev, Radmila
中科院分区：
文献类型：
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作者：
Dzitoyeva, Svetlana;Imbesi, Marta;Manev, Radmila
咖啡酸是一种抑制 5-脂氧合酶 (5-LOX) 的天然化合物。在小鼠中，咖啡酸产生类似抗抑郁的作用，并减轻强迫游泳引起的皮质脑源性神经营养因子 (BDNF) mRNA 的减少。我们使用野生型和 5-LOX 缺陷小鼠，发现游泳降低了 BDNF 外显子 IV 的皮质含量，但没有降低外显子 I mRNA 的含量。在野生型小鼠中，咖啡酸可以减弱 BDNF 转录物 IV 的降低，但在 5-LOX 缺陷小鼠中则不然，这表明 5-LOX 在 BDNF 调节中发挥着作用。
Caffeic acid is a natural compound that inhibits 5-lipoxygenase (5-LOX). In mice, caffeic acid produces antidepressant-like effects and attenuates the decrease in cortical brain-derived neurotrophic factor (BDNF) mRNA induced by forced swimming. We used wild-type and 5-LOX-deficient mice and found that swimming reduced the cortical content of BDNF exon IV but not exon I mRNA. The BDNF transcript IV decrease was attenuated by caffeic acid in wild-type but not in 5-LOX-deficient mice, suggesting a role for 5-LOX in BDNF regulation.