Cytochrome c oxidase dysfunction in sepsis
Cytochrome c oxidase dysfunction in sepsis
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DOI：
10.1097/01.ccm.0000278604.93569.27
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发表时间：
2007-09-01
影响因子：
8.8
通讯作者：
Deutschman, Clifford S.
中科院分区：
文献类型：
--
作者：
Levy, Richard J.;Deutschman, Clifford S.
脓毒症是危重病人死亡的主要原因，与组织氧摄取受损有关。一种可能的解释是线粒体功能障碍和无效的氧气利用。这种异常被称为细胞病理性缺氧。这可能是由于电子沿着线粒体内膜上的细胞色素链向下传输的异常所致。在这篇文章中，我们回顾了我们对复合体IV(细胞色素氧化酶)功能异常的研究，它是这一链中的最终电子受体。此外，我们提供的证据表明，给予细胞色素c可以克服这些异常，并提供一种新的治疗替代方案。(《危重医疗》2007；35[补充]：S468-S475)
Sepsis, the principal cause of death in critically ill patients, is associated with impaired oxygen extraction by tissues. One possible explanation is the development of mitochondrial dysfunction and ineffective oxygen utilization. This abnormality has been termed cytopathic hypoxia. This may be caused by an abnormality in the transport of electrons down the cytochrome chain on the mitochondrial inner membrane. In this article we review our studies on abnormalities in the function of complex IV (cytochrome oxidase), the final electron acceptor in this chain. In addition, we provide evidence that administration of cytochrome c may overcome these abnormalities and provide a novel therapeutic alternative. (Crit Care Med 2007; 35[Suppl.]:S468-S475)