Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone/CRH test results in depressed patients
Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone/CRH test results in depressed patients
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DOI：
10.1016/j.psyneuen.2006.06.002
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发表时间：
2006-09-01
影响因子：
3.7
通讯作者：
Bondy, Brigitta
中科院分区：
文献类型：
--
作者：
Schuele, Cornelius;Zill, Peter;Bondy, Brigitta
数据表明，神经营养和下丘脑-垂体-肾上腺皮质（HPA）系统都参与抑郁症的病理生理。本研究旨在探讨非保守性脑源性神经营养因子（BDNF） Val66Met多态性是否对抑郁症患者HPA轴活性有影响。入院时，对187例患有重度抑郁症或双相情感障碍抑郁状态（DSM-IV标准）的无药住院患者进行地塞米松/CRH （DEX/CRH）检测。利用荧光共振能量转移法（FRET）对BDNF Val66Met多态性进行基因分型。在DEX/CRH测试中，Met/Met基因型纯合子携带者的HPA轴活性明显高于Val/Val或Val/Met基因型（ACTH，皮质醇）的患者。我们的研究结果进一步支持了抑郁症中HPA轴失调与神经可塑性降低之间的关联假设，并与BDNF是一种应激反应性细胞间信使修饰HPA轴活性的假设一致。(c) 2006 Elsevier Ltd.版权所有。
Data suggest that both neurotrophic and hypothalamic-pituitary-adrenocortical (HPA) systems are involved in the pathophysiology of depression. The aim of the present study was to investigate whether the non-conservative brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has an impact on HPA axis activity in depressed patients. At admission, the dexamethasone/CRH (DEX/CRH) test was performed in 187 drug-free in-patients suffering from major depression or depressed state of bipolar disorder (DSM-IV criteria). Moreover, genotyping of BDNF Val66Met polymorphism was carried out using the fluorescence resonance energy transfer method (FRET). Homozygous carriers of the Met/Met genotype showed a significantly higher HPA axis activity during the DEX/CRH test than patients carrying the Val/Val or Val/Met genotype (ACTH, cortisol). Our results further contribute to the hypothesized association between HPA axis dysregulation and reduced neuroplasticity in depression and are consistent with the assumption that BDNF is a stress-responsive intercellular messenger modifying HPA axis activity. (c) 2006 Elsevier Ltd. All rights reserved.